A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates.

A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates. Research Abstract Details 

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A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates. Abstract Text:

S K Lynch,M D Mullett,J E Graeber,M J Polak,S K Lynch,M D Mullett,J E Graeber,M J Polak,

Objective:We compared responses to bolus infusion of 5% albumin (ALB) or normal saline (NS) for hypotension in neonates.Study Design:Hypotensive infants were given 10 ml kg(-1) of NS or ALB. A second bolus was given for persistent hypotension. Dopamine therapy was started for hypotension after the second bolus. The primary response was increase in arterial blood pressure toward normal range 1 h postinfusion. Secondary measures included duration of normotension, meeting criteria for second bolus, meeting criteria for vasopressor support and cost comparison.Result:Those receiving ALB (N=49 ALB and 52 NS) were more likely to achieve a normotensive state (ALB=57.1%, NS=32.1% P=0.01) 1 h following the initial bolus therapy. Subsequently, the NS group was also more likely to qualify for vasopressor infusion (ALB=24.5%, NS=44.2% P=0.02). Overall cost for either therapy was equivalent.Conclusion:In hypotensive neonates, ALB results in a greater likelihood of achieving normotension and decreased subsequent use of vasopressors when compared to NS.Journal of Perinatology (2008) 28, 29-33; doi:10.1038/sj.jp.7211846; published online 8 November 2007.

A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates. Publishing Authors By Initials

SK Lynch,MD Mullett,JE Graeber,MJ Polak,SK Lynch,MD Mullett,JE Graeber,MJ Polak,

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A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of perinatology : official journal of the

VOLUME: 28

Page Numbers: 29-33

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ISSN: 0743-8346

DAY: 8

MONTH: 11

YEAR: 2007

A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates. Information

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LANGUAGE: eng

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AFFILIATION: 1Department of Pediatrics, Section of Neonatology, West Virginia University School of Medicine, Morgantown, WV, USA.

Country: United States

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MEDLINETA: J Perinatol

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