A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years.

A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years. Research Abstract Details 

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A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years. Abstract Text:

Bettina S Nedergaard,Morten Ladekarl,Jens Randel Nyengaard,Karsten Nielsen,Bettina S Nedergaard,Morten Ladekarl,Jens Randel Nyengaard,Karsten Nielsen,Bettina S Nedergaard,Morten Ladekarl,Jens Randel Nyengaard,Karsten Nielsen,

OBJECTIVE: The purpose of this study was to investigate possible differences in the primary in situ cellular immune response between patients with and without relapse of Stage IB cervical squamous cell carcinoma. METHOD: Paraffin-embedded tissue from 40 patients (20 with and 20 without relapse) was evaluated. Sections were immunostained for CD1a(+), CD3(+), CD4(+), CD8(+), CD20(+), CD45RA(+), CD45RO(+), CD57(+), CD68(+) and GrB(+) cells. Immune cell profile densities were estimated using stereology. RESULTS: We found significantly lower densities of CD3(+), CD4(+), CD8(+) and CD57(+) cells (both intra- and peritumoral) in tissue from patients who had relapse. Also densities of intratumoral CD1a(+) cells and peritumoral CD20(+), CD45RA(+) and CD45RO(+) cells were significantly lower among patients with relapse. CONCLUSION: This study demonstrates striking differences in the cellular immune response between patients with and without relapse within 5 years. The results are of potential value in adjuvant immunotherapy and prediction of prognosis.

A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years. Publishing Authors By Initials

BS Nedergaard,M Ladekarl,JR Nyengaard,K Nielsen,BS Nedergaard,M Ladekarl,JR Nyengaard,K Nielsen,BS Nedergaard,M Ladekarl,JR Nyengaard,K Nielsen,

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A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gynecologic oncology

VOLUME: 108

Page Numbers: 106-11

Journal Abbreviation: Gynecol. Oncol.

ISSN: 1095-6859

DAY: 22

MONTH: 10

YEAR: 2007

A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years. Information

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LANGUAGE: eng

NlmUniqueID: 365304

A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years. Keywords Mesh Terms:

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Grant and Affiliation Information for A comparative study of the cellular immune response in patients with stage IB cervical squamous cell carcinoma. Low numbers of several immune cell subtypes are strongly associated with relapse of disease within 5 years.

AFFILIATION: Department of Oncology, Aalborg Hospital, Aarhus University Hospital, Denmark.

Country: United States

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MEDLINETA: Gynecol Oncol

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