A comparative review of conventional and lipid formulations of amphotericin B.

A comparative review of conventional and lipid formulations of amphotericin B. Research Abstract Details 

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A comparative review of conventional and lipid formulations of amphotericin B. Abstract Text:

Over the past 15 years, factors suh as corticosteroid treatment, cytotoxic chemotherapy, excessive use of broad spectrum antibiotics and HIV have led to an increased risk of serious fungal infections in both adults and pediatric patients. This increase in invasive fungal infections poses increasing difficulty in their treatment. Three new lipid formulations of amphotericin B are now available in the U.S.: amphotericin B lipid complex (Abelcet), amphotericin B colloidal dispersion (Amphotec), and liposomal amphotericin B (AmBisome). These newer formulations are substantially more expensive, but allow patients to receive higher doses for longer periods of time with decreased renal toxicity than conventional amphotericin B. The properties of these new agents are summarized in this review. Discussion of current national guidelines as well as those used at our institution are presented to provide guidance for the development of institution specific guidelines for the most cost-effective drug for most patients, some may benefit more from one of the newer lipid formulations.

A comparative review of conventional and lipid formulations of amphotericin B. Publishing Authors By Initials

For similar bacterial infections and mycoses: mycoses research abstracts see: bacterial infections and mycoses: mycoses research

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A comparative review of conventional and lipid formulations of amphotericin B. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 24

Page Numbers: 249-57

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Aug

YEAR: 1999

A comparative review of conventional and lipid formulations of amphotericin B. Information

Number of References: 33

LANGUAGE: eng

NlmUniqueID: 8704308

A comparative review of conventional and lipid formulations of amphotericin B. Keywords Mesh Terms:

KEYWORDS: Mycoses

MESH TERMS: economics

Chemical & Substance for Abstract: A comparative review of conventional and lipid formulations of amphotericin B. Information

Substance Name: Amphotericin B

Registry Number: 1397-89-3

Grant and Affiliation Information for A comparative review of conventional and lipid formulations of amphotericin B.

AFFILIATION: Department of Pharmacy, Children's Hospital and College of Pharmacy, Ohio State University, Columbus, USA.

Country: ENGLAND

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MEDLINETA: J Clin Pharm Ther

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