A common neural progenitor for the CNS and PNS.

A common neural progenitor for the CNS and PNS. Research Abstract Details 

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A common neural progenitor for the CNS and PNS. Abstract Text:

T Mujtaba,M Mayer-Proschel,M S Rao,

Cultured spinal cord neuroepithelial (NEP) cells can differentiate into neurons, oligodendrocytes and astrocytes and are morphologically and antigenically distinct from neural crest stem cells (NCSCs) that generate the PNS. NEP cells, however, can generate p75/nestin-immunoreactive cells that are morphologically and antigenically similar to previously characterized NCSCs. NEP-derived p75-immunoreactive cells differentiate into peripheral neurons, smooth muscle, and Schwann cells in mass and clonal culture. Clonal analysis of NEP cells demonstrates that a common NEP progenitor cell generated both CNS and PNS phenotypes. Differentiation into NCSCs was promoted by BMP-2/4 and differentiation did not require cells to divide, indicating that BMP played an instructive role in the differentiation process. Thus, individual NEP cells are multipotent and can differentiate into most major types of cell in the CNS and PNS and that PNS differentiation involves a transition from a NEP stem to another more limited, p75-immunoreactive, neural crest stem cell.

A common neural progenitor for the CNS and PNS. Publishing Authors By Initials

T Mujtaba,M Mayer-Proschel,MS Rao,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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A common neural progenitor for the CNS and PNS. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Developmental biology

VOLUME: 200

Page Numbers: 1-15

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 1

MONTH: Aug

YEAR: 1998

A common neural progenitor for the CNS and PNS. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372762

A common neural progenitor for the CNS and PNS. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: embryology

Chemical & Substance for Abstract: A common neural progenitor for the CNS and PNS. Information

Substance Name: nestin

Registry Number: 0

Grant and Affiliation Information for A common neural progenitor for the CNS and PNS.

AFFILIATION: Department of Neurobiology and Anatomy, Department of Oncological Sciences, University of Utah Medical School, 50 North Medical Drive, Salt Lake City, Utah, 84132, USA.

Country: UNITED STATES

AGENCY: United States NICHD

GRANT: N01-HD-7-3263

ACRONYM: HD

MEDLINETA: Dev Biol

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