A common mitochondrial haplogroup is associated with elevated total serum IgE levels.

A common mitochondrial haplogroup is associated with elevated total serum IgE levels. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A common mitochondrial haplogroup is associated with elevated total serum IgE levels. Abstract Text:

Benjamin A Raby,Barbara Klanderman,Amy Murphy,Salvatore Mazza,Carlos A Camargo,Edwin K Silverman,Scott T Weiss,

BACKGROUND: Maternal history of asthma or atopy is among the most consistently reported risk factors for asthma and atopy in children, yet the molecular basis for this observation remains unclear. Mitochondria are inherited exclusively through the maternal line, raising the possibility that sequence variation in the mitochondrial genome contributes to the pathogenesis of asthma and atopy. OBJECTIVE: We set out to determine whether common European mitochondrial haplogroups are associated with asthma-related atopic phenotypes. METHODS: We studied 654 self-reported white children age 5 to 12 years with mild to moderate asthma participating in the Childhood Asthma Management Program. Eight haplogroup-tagging polymorphisms were genotyped with TaqMan probe hybridization assays, and mitochondrial haplogroup tests of association with asthma-related and atopy-related phenotypes were performed with haplo.stats. RESULTS: We found significant evidence of mitochondrial haplogroup association with total serum IgE levels (global significance, P = .04), with carriers of European haplogroup U (frequency 11%) having higher total serum IgE levels (median level, 684 IU/L) compared with noncarriers (389 IU/L; P = .001). Haplogroup U carriers also had trends of greater skin prick test reactivity (P = .03) and higher frequency of atopic dermatitis (P = .07), although global haplogroup tests for these later 2 phenotypes were not significant at an alpha level of 0.05. CONCLUSION: These data are the first to suggest that common mitochondrial haplogroups influence the atopic diathesis. CLINICAL IMPLICATIONS: These findings may provide a molecular explanation for the prominent influence of maternal history of atopy on the development of atopy in offspring.

A common mitochondrial haplogroup is associated with elevated total serum IgE levels. Publishing Authors By Initials

BA Raby,B Klanderman,A Murphy,S Mazza,CA Camargo,EK Silverman,ST Weiss,

For similar diagnosis: diagnostic techniques and procedures: skin tests research abstracts see: diagnosis: diagnostic techniques and procedures: skin tests research

PUBMED ID PMID:

MEDLINE DATE:

A common mitochondrial haplogroup is associated with elevated total serum IgE levels. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of allergy and clinical immunology

VOLUME: 120

Page Numbers: 351-8

Journal Abbreviation: J. Allergy Clin. Immunol.

ISSN: 0091-6749

DAY: 3

MONTH: Aug

YEAR: 2007

A common mitochondrial haplogroup is associated with elevated total serum IgE levels. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1275002

A common mitochondrial haplogroup is associated with elevated total serum IgE levels. Keywords Mesh Terms:

KEYWORDS: Skin Tests

MESH TERMS: genetics

Chemical & Substance for Abstract: A common mitochondrial haplogroup is associated with elevated total serum IgE levels. Information

Substance Name: Immunoglobulin E

Registry Number: 37341-29-0

Grant and Affiliation Information for A common mitochondrial haplogroup is associated with elevated total serum IgE levels.

AFFILIATION: Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA. benjamin.raby@channing.harvard.edu

Country: United States

AGENCY: United States NHLBI

GRANT: T32 HL07427

ACRONYM: HL

MEDLINETA: J Allergy Clin Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A common mitochondrial haplogroup is associated with elevated total serum IgE levels Related Publications

• A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells.
• Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala.
• Alcohol and the elderly: an overlooked phenomenon in the literature in developing countries-the Israeli case.
• BMP-2 inhibits proliferation of human aortic smooth muscle cells via p21Cip1/Waf1.
• CD8+ T-cell priming during a central nervous system infection with mouse hepatitis virus.
• Catalytic enantioselective synthesis of adociacetylene B.
• Cis-->trans and trans-->cis isomerizations of styrylcoumarins in the solid state. Importance of the location of free volume in crystal lattices.
• Comparison of photophysical and colloidal properties of biocompatible semiconductor nanocrystals using fluorescence correlation spectroscopy.
• Computational modeling of multicellular constructs with the material point method.
• Depression and quality of life issues in patients with amyotrophic lateral sclerosis.
• Disclosures of illness by doctors to their patients: a qualitative study of doctors with HIV and other serious disorders.
• Hepatocyte antigen as a marker of intestinal metaplasia.
• Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma.
• Isolation of a novel platelet-derived growth factor-responsive precursor from the embryonic ventral forebrain.
• New concepts of multiple tests and their use for evaluating high-dimensional EEG data.
• Nonlinear dynamics of paced cardiac cells.
• Pathway analysis of kidney cancer using proteomics and metabolic profiling.
• Pharmacogenomics: challenges and opportunities.
• Role of the replicase gene of murine coronavirus JHM strain in hepatitis.
• Scoliosis: a journal dedicated to multidisciplinary research on prevention, control, and treatment of scoliosis and other spinal deformities.
• Seeking safety therapy for adolescent girls with PTSD and substance use disorder: a randomized controlled trial.
• Shot-noise limited single-molecule FRET histograms: comparison between theory and experiments.
• Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.
• Stoichiometry of a pore mutation that abolishes picrotoxin-mediated antagonism of the GABAA receptor.
• System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiae.
• The transmission of bluetongue virus by embryo transfer in sheep.
• Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy.
• Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: single extrasystoles.
• Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 2: multiple extrasystoles.
• Why do we treat adolescent idiopathic scoliosis? What we want to obtain and to avoid for our patients. SOSORT 2005 Consensus paper.