A common mechanism underlies stretch activation and receptor activation of TRPC6 channels.

A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Research Abstract Details 

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A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Abstract Text:

Maria A Spassova,Thamara Hewavitharana,Wen Xu,Jonathan Soboloff,Donald L Gill,

The TRP family of ion channels transduce an extensive range of chemical and physical signals. TRPC6 is a receptor-activated nonselective cation channel expressed widely in vascular smooth muscle and other cell types. We report here that TRPC6 is also a sensor of mechanically and osmotically induced membrane stretch. Pressure-induced activation of TRPC6 was independent of phospholipase C. The stretch responses were blocked by the tarantula peptide, GsMTx-4, known to specifically inhibit mechanosensitive channels by modifying the external lipid-channel boundary. The GsMTx-4 peptide also blocked the activation of TRPC6 channels by either receptor-induced PLC activation or by direct application of diacylglycerol. The effects of the peptide on both stretch- and diacylglycerol-mediated TRPC6 activation indicate that the mechanical and chemical lipid sensing by the channel has a common molecular mechanism that may involve lateral-lipid tension. The mechanosensing properties of TRPC6 channels highly expressed in smooth muscle cells are likely to play a key role in regulating myogenic tone in vascular tissue.

A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Publishing Authors By Initials

MA Spassova,T Hewavitharana,W Xu,J Soboloff,DL Gill,

For similar proteins: carrier proteins: membrane transport proteins: ion channels: transient receptor potential channels: trpc cation channels research abstracts see: proteins: carrier proteins: membrane transport proteins: ion channels: transient receptor potential channels: trpc cation channels research

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A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 16586-91

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 20

MONTH: 10

YEAR: 2006

A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Keywords Mesh Terms:

KEYWORDS: TRPC Cation Channels

MESH TERMS: metabolism

Chemical & Substance for Abstract: A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Information

Substance Name: TRPC Cation Channels

Registry Number: 0

Grant and Affiliation Information for A common mechanism underlies stretch activation and receptor activation of TRPC6 channels.

AFFILIATION: Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, MD 21201, USA. mspas001@umaryland.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL 55426

ACRONYM: HL

MEDLINETA: Proc Natl Acad Sci U S A

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