A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis.

A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Research Abstract Details 

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A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Abstract Text:

Fusion of vesicles into target membranes during many types of regulated exocytosis requires both SNARE-complex proteins and fusogenic lipids, such as phosphatidic acid. Mitochondrial fusion is less well understood but distinct, as it is mediated instead by the protein Mitofusin (Mfn). Here, we identify an ancestral member of the phospholipase D (PLD) superfamily of lipid-modifying enzymes that is required for mitochondrial fusion. Mitochondrial PLD (MitoPLD) targets to the external face of mitochondria and promotes trans-mitochondrial membrane adherence in a Mfn-dependent manner by hydrolysing cardiolipin to generate phosphatidic acid. These findings reveal that although mitochondrial fusion and regulated exocytic fusion are mediated by distinct sets of protein machinery, the underlying processes are unexpectedly linked by the generation of a common fusogenic lipid. Moreover, our findings suggest a novel basis for the mitochondrial fragmentation observed during apoptosis.

A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Publishing Authors By Initials

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nature cell biology

VOLUME: 8

Page Numbers: 1255-62

Journal Abbreviation: Nat. Cell Biol.

ISSN: 1465-7392

DAY: 8

MONTH: 10

YEAR: 2006

A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Information

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LANGUAGE: eng

NlmUniqueID: 100890575

A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: physiology

Chemical & Substance for Abstract: A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis. Information

Substance Name: Mfn1 protein, mouse

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for A common lipid links Mfn-mediated mitochondrial fusion and SNARE-regulated exocytosis.

AFFILIATION: Graduate Program in Molecular and Cellular Biology, Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794-5140, USA.

Country: England

AGENCY: United States PHS

GRANT: 71520

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MEDLINETA: Nat Cell Biol

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