A commentary on gestational programming and functions of HLA-G in pregnancy.

A commentary on gestational programming and functions of HLA-G in pregnancy. Research Abstract Details 

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A commentary on gestational programming and functions of HLA-G in pregnancy. Abstract Text:

J S Hunt,P J Morales,J L Pace,A T Fazleabas,D K Langat,

HLA-G is an HLA class Ib gene that is highly expressed in human trophoblast cells. The single HLA-G mRNA is alternatively spliced to generate at least seven transcripts, three of which encode soluble isoforms. Many studies have shown that high levels of soluble antigens are associated with successful implantation and graft acceptance. To study expression, regulation and functions of two of the soluble isoforms, HLA-G5 and HLA-G6, we generated recombinant proteins in eukaryotic cells and developed monoclonal antibodies specific for each of the two proteins. In addition, we investigated the olive baboon Paan-AG gene as a potential functional correlate of HLA-G. Here, we present summaries of the studies that have been conducted in our laboratory using these tools and discuss the results within the context of the research on this topic that is ongoing in ours and other laboratories worldwide. Collectively, the data indicate that soluble HLA-G is a critical contributor to immune privilege in pregnancy and imply that this placenta-derived substance may impact other pathways leading to successful reproduction.

A commentary on gestational programming and functions of HLA-G in pregnancy. Publishing Authors By Initials

JS Hunt,PJ Morales,JL Pace,AT Fazleabas,DK Langat,

For similar cells: trophoblasts research abstracts see: cells: trophoblasts research

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A commentary on gestational programming and functions of HLA-G in pregnancy. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Placenta

VOLUME: 28 Suppl A

Page Numbers: S57-63

Journal Abbreviation:

ISSN: 0143-4004

DAY: 9

MONTH: 03

YEAR: 2007

A commentary on gestational programming and functions of HLA-G in pregnancy. Information

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LANGUAGE: eng

NlmUniqueID: 8006349

A commentary on gestational programming and functions of HLA-G in pregnancy. Keywords Mesh Terms:

KEYWORDS: Trophoblasts

MESH TERMS: immunology

Chemical & Substance for Abstract: A commentary on gestational programming and functions of HLA-G in pregnancy. Information

Substance Name: Receptors, Immunologic

Registry Number: 0

Grant and Affiliation Information for A commentary on gestational programming and functions of HLA-G in pregnancy.

AFFILIATION: Department of Anatomy and Cell Biology, University of Kansas Medical Center, Mail Stop 3038, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA. jhunt@kumc.edu

Country: England

AGENCY: United States NICHD

GRANT: R01 HD33994

ACRONYM: HD

MEDLINETA: Placenta

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