A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Abstract Text:

Recent studies suggest that thousands of genes may contribute to breast cancer pathophysiologies when deregulated by genomic or epigenomic events. Here, we describe a model "system" to appraise the functional contributions of these genes to breast cancer subsets. In general, the recurrent genomic and transcriptional characteristics of 51 breast cancer cell lines mirror those of 145 primary breast tumors, although some significant differences are documented. The cell lines that comprise the system also exhibit the substantial genomic, transcriptional, and biological heterogeneity found in primary tumors. We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations.

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Publishing Authors By Initials

For similar proteins: neoplasm proteins research abstracts see: proteins: neoplasm proteins research

PUBMED ID PMID:

MEDLINE DATE:

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer cell

VOLUME: 10

Page Numbers: 515-27

Journal Abbreviation: Cancer Cell

ISSN: 1535-6108

DAY: 3

MONTH: Dec

YEAR: 2006

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101130617

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Keywords Mesh Terms:

KEYWORDS: Neoplasm Proteins

MESH TERMS: analysis

Chemical & Substance for Abstract: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Information

Substance Name: Neoplasm Proteins

Registry Number: 0

Grant and Affiliation Information for A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.

AFFILIATION: Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94270, USA. rmneve@lbl.gov

Country: United States

AGENCY: United States NCI

GRANT: CA112970

ACRONYM: CA

MEDLINETA: Cancer Cell

REFSOURCE: Cancer Cell. 2006 Dec;10(6):453-4

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Related Publications

• A Modification of the Helmholtz Theory of Hearing.
• A case for consistent assignment.
• A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
• A gain-of-function mutation in the Arabidopsis pleiotropic drug resistance transporter PDR9 confers resistance to auxinic herbicides.
• Auxin signaling.
• Bone anchored hearing aids: a second fixture reduces auditory deprivation in Cambridge.
• Book review: Cancer pain relief and palliative care in children WHO Publication, Geneva 1998.
• Characterization of Bizzy Nut extracts in estrogen-responsive MCF-7 breast cancer cells.
• Colorimetric broth microdilution method for the antifungal screening of plant extracts against yeasts.
• Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda.
• Cost-effectiveness analyses alongside randomised clinical trials.
• Cyclometalated iridium(iii)-sensitized titanium dioxide solar cells.
• Do men hold African-American and Caucasian women to different standards of beauty?
• Effect of holding time and temperature of bovine whole blood on concentration of progesterone, estradiol-17beta and estrone in plasma and serum samples.
• Local motions in a benchmark of allosteric proteins.
• Mental health nurse supplementary prescribing: experiences of mental health nurses, psychiatrists and patients.
• Natural product research: the challenges facing the modern researcher.
• Nicotinamidase activity is important for germination.
• Noise produced by vacuuming exceeds the hearing thresholds of C57Bl/6 and CD1 mice.
• Parallel tool industries in New Caledonian crows.
• Parental concerns and distress after paediatric traumatic brain injury: a qualitative study.
• Population-based study of home accessibility features and the activities of daily living: clinical and policy implications.
• Recombinant simian varicella viruses induce immune responses to simian immunodeficiency virus (SIV) antigens in immunized vervet monkeys.
• Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda.
• Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction.
• Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy.
• Simian varicella virus expresses a latency-associated transcript that is antisense to open reading frame 61 (ICP0) mRNA in neural ganglia of latently infected monkeys.
• Smoking and health: New insights and recent developments.
• The problem of consent in emergency medicine research.
• The relationship between phonological memory, receptive vocabulary, and fast mapping in young children with specific language impairment.