A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolevulinate into nodular Basal cell carcinoma of the skin.

A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolevulinate into nodular Basal cell carcinoma of the skin. Research Abstract Details 

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A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolevulinate into nodular Basal cell carcinoma of the skin. Abstract Text:

S Campbell,Andrew Pye,S Horton,J Matthew,P Helliwell,Alison Curnow,S Campbell,Andrew Pye,S Horton,J Matthew,P Helliwell,Alison Curnow,

This investigation considered a novel method of enhancing penetration of the topical photosensitizing agent methyl aminolevulinate (MAL) into nodular basal cell carcinomas (BCCs) using an oxygen pressure injection device. Oxygen pressure injection (OPI) is a method to drive compounds into skin using pressured oxygen. The study was an observer-blinded pilot of a single application of MAL to nBCCs, with or without the use of OPI. The BCCs were then excised at different time intervals (0-180 min) and the depth of penetration of the MAL examined using microscopic fluorescence photometry to detect the production of the naturally fluorescent active photosensitiser protoporphyrin IX (PpIX). A highly selective and homogeneous distribution of MAL-induced porphyrin fluorescence was seen in all nBCC tumors studied, and showed a high lesion-to-normal-tissue ratio with very little fluorescence in the surrounding normal tissue. Although it was difficult to compare quantitatively, as individual tumors in each of the different study groups varied, a definite trend of increase in relative tumor concentration of MAL-induced PpIX was observed over time, and this was enhanced when OPI was employed.

A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolevulinate into nodular Basal cell carcinoma of the skin. Publishing Authors By Initials

S Campbell,A Pye,S Horton,J Matthew,P Helliwell,A Curnow,S Campbell,A Pye,S Horton,J Matthew,P Helliwell,A Curnow,

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A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolevulinate into nodular Basal cell carcinoma of the skin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of environmental pathology, toxicology and

VOLUME: 26

Page Numbers: 295-303

Journal Abbreviation: J. Environ. Pathol. Toxicol. O

ISSN: 0731-8898

DAY: 16

MONTH: 01

YEAR: 2007

A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolevulinate into nodular Basal cell carcinoma of the skin. Information

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LANGUAGE: eng

NlmUniqueID: 8501420

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Grant and Affiliation Information for A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolevulinate into nodular Basal cell carcinoma of the skin.

AFFILIATION: Cornwall Dermatology Research, Peninsula Medical School, Truro, UK TR1 3HD.

Country: United States

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MEDLINETA: J Environ Pathol Toxicol Oncol

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