[A clinical application of histidine buffered cardioplegia]

[A clinical application of histidine buffered cardioplegia] Research Abstract Details 

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[A clinical application of histidine buffered cardioplegia] Abstract Text:

K Takeuchi,K Maida,S Yoshida,S Suzuki,P J del Nido,S Tanaka,

Blood cardioplegia has been widely accepted due to better oxygen delivery, pH buffering and free radical scavenge. We have found that a crystalloid cardioplegia solution formulated to accelerate anaerobic glycolysis with high buffering capacity. To conserve blood cardioplegia, we formulated a crystalloid cardiopletia containing 100 mM histidine for buffering. This cardioplegia (HBS) was compared to cold blood cardioplegia in patients requiring open heart surgery. Eighty patients including HBS (n = 28), and CBC (n = 40) were involved in this study. Left ventricular end-systolic elastance (Emax; mmHg/cm3) was evaluated pre- and postoperatively. Cardiac index and inotropic requirement were also monitored at 1, 3, and 12 hours after cardiopulmonary bypass. There was no death in either group. All hearts returned to previous rhythm in HBS group, whereas total 12 DC cardioversions were requested in 6 patients. Emax was significantly higher in HBS group (5.2 +/- 0.6 mmHg/cm3) than in CBC group (3.4 +/- 0.4 mmHg/cm3). Cardiac index was also significantly higher in HBS group postoperatively than in CBC group with lower inotropic requirements. We conclude that histidine containing crystalloid cardioplegia provides excellent recovery of cardiac performance with lower inotropic requirements in open heart surgery. The ease of use, and lack of blood are other important advantages of this crystalloid cardioplegia.

[A clinical application of histidine buffered cardioplegia] Publishing Authors By Initials

K Takeuchi,K Maida,S Yoshida,S Suzuki,PJ del Nido,S Tanaka,

For similar inorganic chemicals: potassium compounds research abstracts see: inorganic chemicals: potassium compounds research

PUBMED ID PMID:

MEDLINE DATE:

[A clinical application of histidine buffered cardioplegia] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: [Zasshi] [Journal]. Nihon Ky?bu Geka Gakkai

VOLUME: 45

Page Numbers: 1715-9

Journal Abbreviation:

ISSN: 0369-4739

DAY: 14

MONTH: Oct

YEAR: 1997

[A clinical application of histidine buffered cardioplegia] Information

Number of References:

LANGUAGE: jpn

NlmUniqueID: 19130180

[A clinical application of histidine buffered cardioplegia] Keywords Mesh Terms:

KEYWORDS: Potassium Compounds

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: [A clinical application of histidine buffered cardioplegia] Information

Substance Name: Histidine

Registry Number: 71-00-1

Grant and Affiliation Information for [A clinical application of histidine buffered cardioplegia]

AFFILIATION: Department of Cardiovascular Surgery, Aomori General Hospital, Japan.

Country: JAPAN

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MEDLINETA: Nippon Kyobu Geka Gakkai Zassh

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