A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals.

A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals. Research Abstract Details 

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A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals. Abstract Text:

Bradley Greger,Babak Kateb,Peter Gruen,Paul H Patterson,

We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical "signatures" of therapeutically useful drugs.

A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals. Publishing Authors By Initials

B Greger,B Kateb,P Gruen,PH Patterson,

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A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroscience methods

VOLUME: 163

Page Numbers: 321-5

Journal Abbreviation: J. Neurosci. Methods

ISSN: 0165-0270

DAY: 5

MONTH: 04

YEAR: 2007

A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals. Information

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LANGUAGE: eng

NlmUniqueID: 7905558

A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals. Keywords Mesh Terms:

KEYWORDS: Signal Processing, Computer-Assisted

MESH TERMS: methods

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Grant and Affiliation Information for A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals.

AFFILIATION: University of Utah, Department of Bioengineering, Salt Lake City, UT 84112, United States. bradley.greger@utah.edu

Country: Netherlands

AGENCY: United States NEI

GRANT: R01 EY0155445

ACRONYM: EY

MEDLINETA: J Neurosci Methods

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