A chromatin-mediated mechanism for specification of conditional transcription factor targets.

A chromatin-mediated mechanism for specification of conditional transcription factor targets. Research Abstract Details 

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A chromatin-mediated mechanism for specification of conditional transcription factor targets. Abstract Text:

Michael J Buck,Jason D Lieb,

Organisms respond to changes in their environment, and many such responses are initiated at the level of gene transcription. Here, we provide evidence for a previously undiscovered mechanism for directing transcriptional regulators to new binding targets in response to an environmental change. We show that repressor-activator protein 1 (Rap1), a master regulator of yeast metabolism, binds to an expanded target set after glucose depletion despite decreasing protein levels and no evidence of posttranslational modification. Computational analysis predicts that proteins capable of recruiting the chromatin regulator Tup1 act to restrict the binding distribution of Rap1 in the presence of glucose. Deletion of the gene(s) encoding Tup1, recruiters of Tup1 or chromatin regulators recruited by Tup1 cause Rap1 to bind specifically and inappropriately to low-glucose targets. These data, combined with whole-genome measurements of nucleosome occupancy and Tup1 distribution, provide evidence for a mechanism of dynamic target specification that coordinates the genome-wide distribution of intermediate-affinity DNA sequence motifs with chromatin-mediated regulation of accessibility to those sites.

A chromatin-mediated mechanism for specification of conditional transcription factor targets. Publishing Authors By Initials

MJ Buck,JD Lieb,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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A chromatin-mediated mechanism for specification of conditional transcription factor targets. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nature genetics

VOLUME: 38

Page Numbers: 1446-51

Journal Abbreviation: Nat. Genet.

ISSN: 1061-4036

DAY: 12

MONTH: 11

YEAR: 2006

A chromatin-mediated mechanism for specification of conditional transcription factor targets. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9216904

A chromatin-mediated mechanism for specification of conditional transcription factor targets. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: A chromatin-mediated mechanism for specification of conditional transcription factor targets. Information

Substance Name: TUP1 protein, S cerevisiae

Registry Number: 133135-32-7

Grant and Affiliation Information for A chromatin-mediated mechanism for specification of conditional transcription factor targets.

AFFILIATION: Department of Biology and the Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Country: United States

AGENCY: United States NHGRI

GRANT: HG0029989

ACRONYM: HG

MEDLINETA: Nat Genet

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