A chromatin landmark and transcription initiation at most promoters in human cells.

A chromatin landmark and transcription initiation at most promoters in human cells. Research Abstract Details 

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A chromatin landmark and transcription initiation at most promoters in human cells. Abstract Text:

Matthew C Lorincz,Dirk ,

We describe the results of a genome-wide analysis of human cells that suggests that most protein-coding genes, including most genes thought to be transcriptionally inactive, experience transcription initiation. We found that nucleosomes with H3K4me3 and H3K9,14Ac modifications, together with RNA polymerase II, occupy the promoters of most protein-coding genes in human embryonic stem cells. Only a subset of these genes produce detectable full-length transcripts and are occupied by nucleosomes with H3K36me3 modifications, a hallmark of elongation. The other genes experience transcription initiation but show no evidence of elongation, suggesting that they are predominantly regulated at postinitiation steps. Genes encoding most developmental regulators fall into this group. Our results also identify a class of genes that are excluded from experiencing transcription initiation, at which mechanisms that prevent initiation must predominate. These observations extend to differentiated cells, suggesting that transcription initiation at most genes is a general phenomenon in human cells.

A chromatin landmark and transcription initiation at most promoters in human cells. Publishing Authors By Initials

MC Lorincz,D ,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

PUBMED ID PMID:

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A chromatin landmark and transcription initiation at most promoters in human cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cell

VOLUME: 130

Page Numbers: 77-88

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 13

MONTH: Jul

YEAR: 2007

A chromatin landmark and transcription initiation at most promoters in human cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413066

A chromatin landmark and transcription initiation at most promoters in human cells. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: A chromatin landmark and transcription initiation at most promoters in human cells. Information

Substance Name: RNA Polymerase II

Registry Number: EC 2.7.7.-

Grant and Affiliation Information for A chromatin landmark and transcription initiation at most promoters in human cells.

AFFILIATION: Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Country: United States

AGENCY: United States NHGRI

GRANT: HG002668

ACRONYM: HG

MEDLINETA: Cell

REFSOURCE: Cell. 2007 Jul 13;130(1):16-8

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