A cholinergic receptor gene (CHRM2) affects event-related oscillations.

A cholinergic receptor gene (CHRM2) affects event-related oscillations. Research Abstract Details 

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A cholinergic receptor gene (CHRM2) affects event-related oscillations. Abstract Text:

Kevin A Jones,Bernice Porjesz,Laura Almasy,Laura Bierut,Danielle Dick,Alison Goate,Anthony Hinrichs,John P Rice,Jen C Wang,Lance O Bauer,Raymond Crowe,Tatiana Foroud,Victor Hesselbrock,Samuel Kuperman,John Nurnberger,Sean J O'Connor,John Rohrbaugh,Marc A Schuckit,Jay Tischfield,Howard J Edenberg,Henri Begleiter,

We report genetic linkage and association findings which implicate the gene encoding the muscarinic acetylcholine receptor M2 (CHRM2) in the modulation of a scalp-recorded electrophysiological phenotype. The P3 (P300) response was evoked using a three-stimulus visual oddball paradigm and a phenotype that relates to the energy in the theta band (4-5 Hz) was analyzed. Studies have shown that similar electrophysiological measures represent cognitive correlates of attention, working memory, and response selection; a role has been suggested for the ascending cholinergic pathway in the same functions. The results of our genetic association tests, combined with knowledge regarding the presence of presynaptic cholinergic M2 autoreceptors in the basal forebrain, indicate that the cognitive processes required by the experiment may in part be mediated by inhibitory neural networks. These findings underscore the utility of electrophysiology and neurogenetics in the understanding of cognitive function and the study of brain-related disorders.

A cholinergic receptor gene (CHRM2) affects event-related oscillations. Publishing Authors By Initials

KA Jones,B Porjesz,L Almasy,L Bierut,D Dick,A Goate,A Hinrichs,JP Rice,JC Wang,LO Bauer,R Crowe,T Foroud,V Hesselbrock,S Kuperman,J Nurnberger,SJ O'Connor,J Rohrbaugh,MA Schuckit,J Tischfield,HJ Edenberg,H Begleiter,

For similar proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, muscarinic: receptor, muscarinic m2 research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, muscarinic: receptor, muscarinic m2 research

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A cholinergic receptor gene (CHRM2) affects event-related oscillations. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Behavior genetics

VOLUME: 36

Page Numbers: 627-39

Journal Abbreviation: Behav. Genet.

ISSN: 0001-8244

DAY: 3

MONTH: Sep

YEAR: 2006

A cholinergic receptor gene (CHRM2) affects event-related oscillations. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 251711

A cholinergic receptor gene (CHRM2) affects event-related oscillations. Keywords Mesh Terms:

KEYWORDS: Receptor, Muscarinic M2

MESH TERMS: genetics

Chemical & Substance for Abstract: A cholinergic receptor gene (CHRM2) affects event-related oscillations. Information

Substance Name: Receptor, Muscarinic M2

Registry Number: 0

Grant and Affiliation Information for A cholinergic receptor gene (CHRM2) affects event-related oscillations.

AFFILIATION: Department of Psychiatry, SUNY Health Science Center, 450 Clarkson Avenue, Box 1203, Brooklyn, NY 11203, USA. bp@cns.hscbklyn.edu

Country: United States

AGENCY: United States NIAAA

GRANT: U10AA08401

ACRONYM: AA

MEDLINETA: Behav Genet

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