A charged and contoured surface on the nucleosome regulates chromatin compaction.

A charged and contoured surface on the nucleosome regulates chromatin compaction. Research Abstract Details 

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A charged and contoured surface on the nucleosome regulates chromatin compaction. Abstract Text:

Jayanth V Chodaparambil,Andrew J Barbera,Xu Lu,Kenneth M Kaye,Jeffrey C Hansen,Karolin Luger,

Local nucleosome-nucleosome interactions in cis drive chromatin folding, whereas interactions in trans lead to fiber-fiber oligomerization. Here we show that peptides derived from the histone H4 tail and Kaposi's sarcoma herpesvirus LANA protein can replace the endogenous H4 tail, resulting in array folding and oligomerization. Neutralization of a LANA binding site on the histone surface enhanced rather than abolished nucleosome-nucleosome interactions. We maintain that the contoured nucleosome surface is centrally involved in regulating chromatin condensation.

A charged and contoured surface on the nucleosome regulates chromatin compaction. Publishing Authors By Initials

JV Chodaparambil,AJ Barbera,X Lu,KM Kaye,JC Hansen,K Luger,

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A charged and contoured surface on the nucleosome regulates chromatin compaction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature structural & molecular biology

VOLUME: 14

Page Numbers: 1105-7

Journal Abbreviation: Nat. Struct. Mol. Biol.

ISSN: 1545-9985

DAY: 28

MONTH: 10

YEAR: 2007

A charged and contoured surface on the nucleosome regulates chromatin compaction. Information

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LANGUAGE: eng

NlmUniqueID: 101186374

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Grant and Affiliation Information for A charged and contoured surface on the nucleosome regulates chromatin compaction.

AFFILIATION: Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523-1870, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM45916

ACRONYM: GM

MEDLINETA: Nat Struct Mol Biol

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