[A change of immune profile of patients with schizophrenia during treatment]

[A change of immune profile of patients with schizophrenia during treatment] Research Abstract Details 

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[A change of immune profile of patients with schizophrenia during treatment] Abstract Text:

G I Koliaskina,T P Sekirina,L V Androsova,S G Kushner,E F Vasil'eva,O A Burbaeva,M A Morozova,

Cellular and humoral immunological parameters have been studied in 59 schizophrenic patients and 38 healthy controls. Immunological indices (CIC, autoantibodies to cardiolipin) were found to be significantly elevated in patients in the acute disease stage before the treatment. After olanzapin therapy, a level of these parameters decreased and did not differ from that of controls. In patients, irrespective of clinical condition and treatment, functional activity of immunocompetent cells (phagocyte activity of neutrophils and monocytes, cytotoxic activity of lymphocytes natural killers, interleukin-2, interleukin-10 and gamma-interferon production), was significantly lower both before the treatment as after therapy, i.e. did not change during the whole study (28 weeks). In responders, a level of IL-1B production was higher than in controls before and during the treatment. In non-responders, it was similar to that in controls before the therapy, and increased during the treatment to a higher level.

[A change of immune profile of patients with schizophrenia during treatment] Publishing Authors By Initials

GI Koliaskina,TP Sekirina,LV Androsova,SG Kushner,EF Vasil'eva,OA Burbaeva,MA Morozova,

For similar mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research abstracts see: mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research

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MEDLINE DATE:

[A change of immune profile of patients with schizophrenia during treatment] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsak

VOLUME: 104

Page Numbers: 39-45

Journal Abbreviation:

ISSN: 1997-7298

DAY: 31

MONTH: 03

YEAR: 2004

[A change of immune profile of patients with schizophrenia during treatment] Information

Number of References:

LANGUAGE: rus

NlmUniqueID: 9712194

[A change of immune profile of patients with schizophrenia during treatment] Keywords Mesh Terms:

KEYWORDS: Schizophrenia

MESH TERMS: immunology

Chemical & Substance for Abstract: [A change of immune profile of patients with schizophrenia during treatment] Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for [A change of immune profile of patients with schizophrenia during treatment]

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Country: Russia

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MEDLINETA: Zh Nevrol Psikhiatr Im S S Kor

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