A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination.

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Research Abstract Details 

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A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Abstract Text:

Ivo Spiegel,Konstantin Adamsky,Yael Eshed,Ron Milo,Helena Sabanay,Offra Sarig-Nadir,Ido Horresh,Steven S Scherer,Matthew N Rasband,Elior Peles,

Myelination in the peripheral nervous system requires close contact between Schwann cells and the axon, but the underlying molecular basis remains largely unknown. Here we show that cell adhesion molecules (CAMs) of the nectin-like (Necl, also known as SynCAM or Cadm) family mediate Schwann cell-axon interaction during myelination. Necl4 is the main Necl expressed by myelinating Schwann cells and is located along the internodes in direct apposition to Necl1, which is localized on axons. Necl4 serves as the glial binding partner for axonal Necl1, and the interaction between these two CAMs mediates Schwann cell adhesion. The disruption of the interaction between Necl1 and Necl4 by their soluble extracellular domains, or the expression of a dominant-negative Necl4 in Schwann cells, inhibits myelination. These results suggest that Necl proteins are important for mediating axon-glia contact during myelination in peripheral nerves.

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Publishing Authors By Initials

I Spiegel,K Adamsky,Y Eshed,R Milo,H Sabanay,O Sarig-Nadir,I Horresh,SS Scherer,MN Rasband,E Peles,

For similar proteins: neoplasm proteins: tumor suppressor proteins research abstracts see: proteins: neoplasm proteins: tumor suppressor proteins research

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A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Nature neuroscience

VOLUME: 10

Page Numbers: 861-9

Journal Abbreviation: Nat. Neurosci.

ISSN: 1097-6256

DAY: 3

MONTH: 06

YEAR: 2007

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Information

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LANGUAGE: eng

NlmUniqueID: 9809671

A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. Information

Substance Name: RNA

Registry Number: 63231-63-0

Grant and Affiliation Information for A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination.

AFFILIATION: Department of Molecular Cell Biology, The Weizmann Institute of Science, POB 26, Rehovot 76100, Israel.

Country: United States

AGENCY: United States NINDS

GRANT: NS50220

ACRONYM: NS

MEDLINETA: Nat Neurosci

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