A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation.

A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation. Research Abstract Details 

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A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation. Abstract Text:

Oussama Abla,John T Sandlund,Lillian Sung,Penelope Brock,Rob Corbett,Ivan Kirov,Timothy C Griffin,Susan Blaser,Sheila Weitzman,

PURPOSE: To describe the outcome of childhood primary central nervous system lymphoma (PCNSL) treated with chemotherapy alone or with chemotherapy plus cranial radiotherapy (CRT). METHODS: Retrospective chart review of children with PCNSL at six tertiary care pediatric centers. RESULTS: Eight immunocompetent and four immunocompromised children were included. Ten children received chemotherapy alone without CRT, with most receiving high-dose methotrexate and high-dose cytarabine. Five year event-free survival (EFS) in this group was 70.0 +/- 14.5%. Two children received chemotherapy plus CRT; one relapsed and died while the other is alive in remission. Three children died, including two from relapsed disease. The other child with human immunodeficiency virus infection died of an opportunistic infection while in remission following chemotherapy alone. CONCLUSIONS: Most children with PCNSL can achieve long-term remissions with chemotherapy alone without CRT. Multi-center prospective studies are needed to confirm or refute these results in a larger number of patients.

A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation. Publishing Authors By Initials

O Abla,JT Sandlund,L Sung,P Brock,R Corbett,I Kirov,TC Griffin,S Blaser,S Weitzman,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research

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A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric blood & cancer

VOLUME: 47

Page Numbers: 880-5

Journal Abbreviation:

ISSN: 1545-5009

DAY: 3

MONTH: Dec

YEAR: 2006

A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101186624

A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation. Keywords Mesh Terms:

KEYWORDS: Retrospective Studies

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation. Information

Substance Name: Methotrexate

Registry Number: 59-05-2

Grant and Affiliation Information for A case series of pediatric primary central nervous system lymphoma: favorable outcome without cranial irradiation.

AFFILIATION: Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. oussama.abla@sickkids.ca

Country: United States

AGENCY: United States NCI

GRANT: CA 21765

ACRONYM: CA

MEDLINETA: Pediatr Blood Cancer

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