A case report of uncompensated alkalosis induced by daily plasmapheresis in a patient with thrombotic thrombocytopenic purpura.

A case report of uncompensated alkalosis induced by daily plasmapheresis in a patient with thrombotic thrombocytopenic purpura. Research Abstract Details 

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A case report of uncompensated alkalosis induced by daily plasmapheresis in a patient with thrombotic thrombocytopenic purpura. Abstract Text:

Yoshiko Nagai,Mitsuyo Itabashi,Mayuko Mizutani,Tetsuya Ogawa,Wako Yumura,Ken Tsuchiya,Kosaku Nitta,Yoshiko Nagai,Mitsuyo Itabashi,Mayuko Mizutani,Tetsuya Ogawa,Wako Yumura,Ken Tsuchiya,Kosaku Nitta,

Plasmapheresis (PP) is widely known as the standard therapy for thrombotic thrombocytopenic purpura (TTP). Citrate is used as an anticoagulant in fresh frozen plasma, and the large amount of citrate infused during PP induces metabolic alkalosis. A 29-year-old woman was diagnosed with TTP associated with systemic lupus erythematosus, and was treated by daily PP in addition to a steroid, an immunosuppressant, vincristine, and cyclophosphamide. Uncompensated alkalosis caused by a combination of metabolic and respiratory alkalosis developed after artificial ventilation was discontinued. Her metabolic status improved after controlling her respiratory status and the activity of the TTP. Metabolic alkalosis is a common complication in TTP patients treated by frequent PP, but several factors that affect metabolic status may aggravate the alkalosis and induce uncompensated alkalosis.

A case report of uncompensated alkalosis induced by daily plasmapheresis in a patient with thrombotic thrombocytopenic purpura. Publishing Authors By Initials

Y Nagai,M Itabashi,M Mizutani,T Ogawa,W Yumura,K Tsuchiya,K Nitta,Y Nagai,M Itabashi,M Mizutani,T Ogawa,W Yumura,K Tsuchiya,K Nitta,

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A case report of uncompensated alkalosis induced by daily plasmapheresis in a patient with thrombotic thrombocytopenic purpura. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Therapeutic apheresis and dialysis : official peer

VOLUME: 12

Page Numbers: 86-90

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ISSN: 1744-9979

DAY: 8

MONTH: Feb

YEAR: 2008

A case report of uncompensated alkalosis induced by daily plasmapheresis in a patient with thrombotic thrombocytopenic purpura. Information

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LANGUAGE: eng

NlmUniqueID: 101181252

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Grant and Affiliation Information for A case report of uncompensated alkalosis induced by daily plasmapheresis in a patient with thrombotic thrombocytopenic purpura.

AFFILIATION: Department of Medicine IV, Tokyo Women's Medical University, Tokyo, Japan.

Country: Australia

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MEDLINETA: Ther Apher Dial

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