A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis: a case report and review of the literature.

A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis: a case report and review of the literature. Research Abstract Details 

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A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis: a case report and review of the literature. Abstract Text:

Takeshi Kuroda,Mitsuhiro Ueno,Hiroe Sato,Syuuichi Murakami,Minoru Sakatsume,Shinichi Nishi,Masaaki Nakano,Fumitake Gejyo,

In this report, we describe the case of a 50-year-old Japanese woman with Takayasu arteritis who developed severe proteinuria and renal dysfunction. Abdominal computed tomography did not show narrowing of both renal arteries. Although her levels of C-reactive protein were negative, plasma vascular endothelial growth factor (VEGF) and serum interleukin (IL)-6 levels were elevated. Renal biopsy showed glomerulonephropathy mimicking membranoproliferative glomerulonephritis (MPGN) with glomerular capillary wall thickening (double contour). This was accompanied by mesangial cell proliferation and moderate increase of mesangial matrix without deposits of C3. These findings are quite different from MPGN as electron microscopy did not show subendothelial deposit and circumferential mesangial interposition. Here, we present the case of Takayasu arteritis associated with MPGN-like renal manifestation and elevated VEGF and IL-6. The presence of elevated VEGF and IL-6 could be factors that might contribute to MPGN-like appearance.

A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis: a case report and review of the literature. Publishing Authors By Initials

T Kuroda,M Ueno,H Sato,S Murakami,M Sakatsume,S Nishi,M Nakano,F Gejyo,

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A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis: a case report and review of the literature. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Rheumatology international

VOLUME: 27

Page Numbers: 103-7

Journal Abbreviation: Rheumatol. Int.

ISSN: 0172-8172

DAY: 8

MONTH: 07

YEAR: 2006

A case of Takayasu arteritis complicated with glomerulonephropathy mimicking membranoproliferative glomerulonephritis: a case report and review of the literature. Information

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LANGUAGE: eng

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AFFILIATION: Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-Dori, Niigata City, 951-8510, Japan, kurodat@med.niigata-u.ac.jp.

Country: Germany

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MEDLINETA: Rheumatol Int

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