A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage.

A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage. Abstract Text:

Takamitsu Saigusa,Yuichi Kikuchi,Muneharu Yamada,Toshihiko Imakiire,Toshitake Hyodo,Shigenobu Suzuki,Soichiro Miura,

We present a 75-year-old Japanese man with essential thrombocytosis presenting nephrotic syndrome. Proteinuria developed soon after the patient was given a diagnosis of essential thrombocytosis and, 4 years later, it increased to a nephrotic range. Renal biopsy revealed one third of the obtained glomeruli totally sclerotic and the other glomeruli showed a marked thickening of the glomerular basement membrane and mild mesangial proliferation. Remarkable widening of the subendothelial space was evident on electron microscopy. Increased expression of platelet derived growth factor receptor beta was detected in the mesangium and interstitium by immunohistochemistry. Abnormal platelet activation in myeloproliferative disease has been shown to contribute in glomerulosclerosis by releasing various growth factors and cytokines including PDGF. Considering his clinical course and the pathological findings, the probable risk factor for developing severe endothelial damage and glomerulosclerosis is due to the persistence of high platelet count and platelet abnormality.

A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage. Publishing Authors By Initials

T Saigusa,Y Kikuchi,M Yamada,T Imakiire,T Hyodo,S Suzuki,S Miura,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of nephrology

VOLUME: 19

Page Numbers: 656-9

Journal Abbreviation: J. Nephrol.

ISSN: 1121-8428

DAY: 30

MONTH: 11

YEAR: 2006

A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9012268

A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage.

AFFILIATION: Second Department of Internal Medicine, National Defense Medical College, Saitama-Japan. tsaigusa@mtd.biglobe.ne.jp

Country: Italy

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Nephrol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage Related Publications

• 10 modeling lung branching morphogenesis.
• A case of essential thrombocytosis developing nephrotic syndrome and severe endothelial damage.
• A progestin and an estrogen regulate early stages of oogenesis in fish.
• An adult with acute poststreptococcal glomerulonephritis complicated by hemolytic uremic syndrome and nephrotic syndrome.
• Aquatic risk assessment of 2-sulfonato fatty acid methyl ester sodium salt (MES).
• Binding analysis of Xenopus laevis translation initiation factor 4E (eIF4E) in initiation complex formation.
• Carbon Analysis for Inspecting Carbonation of Concrete Using a TEA CO(2) Laser-Induced Plasma.
• Effect of Near-Ultraviolet Light on Alkaloid Production in Multiple Shoot Cultures of Catharanthus roseus.
• Effects of Near-Ultraviolet Light on Alkaloid Production in Catharanthus roseus Plants.
• Effects of pioglitazone and candesartan on renal fibrosis and the intrarenal plasmin cascade in spontaneously hypercholesterolemic rats.
• Follicle-Stimulating Hormone Induces Spermatogenesis Mediated by Androgen Production in Japanese Eel, Anguilla japonica.
• Glycogen synthase kinase-3beta and p38 phosphorylate cyclin D2 on Thr280 to trigger its ubiquitin/proteasome-dependent degradation in hematopoietic cells.
• Imaging polarimetry in patients with neovascular age-related macular degeneration.
• Improvement of the ultraviolet-proof property of silica glass fibers for ArF excimer-laser applications.
• Intracystic adenomyoepithelioma of the breast - case report and review -.
• MFH-1 is required for bone morphogenetic protein-2-induced osteoblastic differentiation of C2C12 myoblasts.
• Novel miniature SPR immunosensor equipped with all-in-one multi-microchannel sensor chip for detecting low-molecular-weight analytes.
• Nuclear receptor structure: implications for function.
• Overexpression of IGF-I receptor in HeLa cells enhances in vivo radioresponse.
• Preparation of infusion for total parenteral nutrition.
• Purification and identification of a glycoprotein that induces the attachment of oncomiracidia of Neobenedenia girellae (Monogenea, Capsalidae).
• Quantitative Determination of Vinblastine in Tissue Cultures of Catharanthus roseus by Radioimmunoassay.
• Radiation-induced senescence-like phenotype in proliferating and plateau-phase vascular endothelial cells.
• Successful imatinib treatment of cardiac involvement of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia followed by severe hepatotoxicity.
• Surface plasmon resonance biosensor for dopamine using D3 dopamine receptor as a biorecognition molecule.
• [A case of recurrent retroperitoneal malignant paraganglioma 25 years after surgery]
• [Coronary artery calcification]
• [Cytogenetical analyses and interpretation of the results in hematopoietic diseases]
• [Reform of health care and medical education]
• t(6;14)(q15;q32) in a patient with CD5+CD10+ diffuse large B-cell lymphoma.