A 65-year-old Japanese man was hospitalized because of acute hepatitis and severe cholestasis due to hepatitis E virus (HEV) infection combined with a drug reaction to a cold preparation. He died of disseminated intravascular coagulation and severe intestinal bleeding due to systemic cytomegalovirus reactivation following the development of severe eruptions with marked eosinophilia due to drug hypersensitivity to taurine and ursodeoxycholate preparations. The close interaction between viral infection or reactivation and drug hypersensitivity was considered as a pathophysiology in this case, which emphasizes the need for further study of the immunological mechanism of the interaction.
A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation. Publishing Authors By Initials
A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation. Journal Published:
PUBLICATION TYPE: Journal Article
Journal: Hepatology research : the official journal of the
VOLUME: 37
Page Numbers: 158-65
Journal Abbreviation: Hepatol. Res.
ISSN: 1386-6346
DAY: 15
MONTH: Feb
YEAR: 2007
A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation. Information
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LANGUAGE: eng
NlmUniqueID: 9711801
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Grant and Affiliation Information for A case of acute hepatitis E associated with multidrug hypersensitivity and cytomegalovirus reactivation.
AFFILIATION: First Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
Country: Netherlands
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MEDLINETA: Hepatol Res
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