[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer]

[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer] Research Abstract Details 

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[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer] Abstract Text:

Kun Chen,Chun-hong Fan,Ming-juan Jin,Liang Song,Hong Xu,Han-qing He,Feng Tong,Kun Chen,Chun-hong Fan,Ming-juan Jin,Liang Song,Hong Xu,Han-qing He,Feng Tong,

OBJECTIVE: To investigate the relationship between sulfotransferase 1Al polymorphism, diet and colorectal cancer susceptibility. METHODS: A case-control study of 140 cancers and 343 health controls was conducted to investigate the role of sulfotransferase 1A1 polymorphism and meat consumption in colorectal carcinogenesis. Genotypes of sulfotransferase 1A1 polymorphism were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: There was no significant difference in allele frequency of SULT1A1 between the control and cancer patient populations. After adjustment for age, sex, smoking and history of diseases, red meat and well-done meat intake showed no significant association with colorectal cancer. Consumption of red meat more than 5 kg per year combined with SULT1Al slow sulfation (Arg/His and His/His) had a statistically significant association with the risk of rectal cancer ( OR = 3.78; 95% CI: 1.08 - 13. 20) compared to that consumed red meat less than 5 kg per year with fast sulfation (Arg/Arg). CONCLUSION: This study suggests that SULT1A1 slow sulfation combined with higher intake of red meat may be associated with an elevated risk of rectal cancer.

[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer] Publishing Authors By Initials

K Chen,CH Fan,MJ Jin,L Song,H Xu,HQ He,F Tong,K Chen,CH Fan,MJ Jin,L Song,H Xu,HQ He,F Tong,

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[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua zhong liu za zhi [Chinese journal of onco

VOLUME: 28

Page Numbers: 670-3

Journal Abbreviation: Zhonghua Zhong Liu Za Zhi

ISSN: 0253-3766

DAY: 5

MONTH: Sep

YEAR: 2006

[A case-control study on the association between the genetic polymorphism of sulfotransferase 1A1, diet and susceptibility of colorectal cancer] Information

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LANGUAGE: chi

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AFFILIATION: Department of Epidemiology, Zhejiang University School of Medicine, Hangzhou 310031, China. CK@zju.edu.cn

Country: China

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MEDLINETA: Zhonghua Zhong Liu Za Zhi

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