A case-control analysis of exposure to traffic and acute myocardial infarction.

A case-control analysis of exposure to traffic and acute myocardial infarction. Research Abstract Details 

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A case-control analysis of exposure to traffic and acute myocardial infarction. Abstract Text:

Cathryn Tonne,Steve Melly,Murray Mittleman,Brent Coull,Robert Goldberg,Joel Schwartz,

BACKGROUND: Long-term exposure to particulate air pollution has been associated with an increased risk of dying from cardiopulmonary and ischemic heart disease, yet few studies have evaluated cardiovascular end points other than mortality. We investigated the relationship between long-term exposure to traffic and occurrence of acute myocardial infarction (AMI) in a case-control study. METHODS: A total of 5,049 confirmed cases of AMI were identified between 1995 and 2003 as part of the Worcester Heart Attack Study, a community-wide study examining changes over time in the incidence of AMI among greater Worcester, Massachusetts, residents. Population controls were selected from Massachusetts resident lists. We used cumulative traffic within 100 m of subjects' residence and distance from major roadway as proxies for exposure to traffic-related air pollution. We estimated the relationship between exposure to traffic and occurrence of AMI using logistic regression, and we adjusted for the following potential confounders: age, sex, section of the study area, point sources emissions of particulate matter with aerodynamic diameter < 2.5 microm, area socioeconomic characteristics, and percentage of open space. RESULTS: An increase in cumulative traffic near the home was associated with a 4% increase in the odds of AMI per interquartile range [95% confidence interval (CI), 2-7%], whereas living near a major roadway was associated with a 5% increase in the odds of AMI per kilometer (95% CI, 3-6%). CONCLUSIONS: These results provide support for an association between long-term exposure to traffic and the risk of AMI.

A case-control analysis of exposure to traffic and acute myocardial infarction. Publishing Authors By Initials

C Tonne,S Melly,M Mittleman,B Coull,R Goldberg,J Schwartz,

For similar complex mixtures: vehicle emissions research abstracts see: complex mixtures: vehicle emissions research

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A case-control analysis of exposure to traffic and acute myocardial infarction. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Environmental health perspectives

VOLUME: 115

Page Numbers: 53-7

Journal Abbreviation: Environ. Health Perspect.

ISSN: 0091-6765

DAY: 3

MONTH: Jan

YEAR: 2007

A case-control analysis of exposure to traffic and acute myocardial infarction. Information

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LANGUAGE: eng

NlmUniqueID: 330411

A case-control analysis of exposure to traffic and acute myocardial infarction. Keywords Mesh Terms:

KEYWORDS: Vehicle Emissions

MESH TERMS: epidemiology

Chemical & Substance for Abstract: A case-control analysis of exposure to traffic and acute myocardial infarction. Information

Substance Name: Vehicle Emissions

Registry Number: 0

Grant and Affiliation Information for A case-control analysis of exposure to traffic and acute myocardial infarction.

AFFILIATION: Department of Environmental Health,Harvard School of Public Health, Boston, Massachusetts, USA. ctonne@hsph.harvard.edu

Country: United States

AGENCY: United States NIEHS

GRANT: T32 ES07155

ACRONYM: ES

MEDLINETA: Environ Health Perspect

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