A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains.

A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Research Abstract Details 

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A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Abstract Text:

N Kimura,M Ueno,K Nakashima,T Taga,

LIM-homeodomain (LHX) transcription factors play critical roles in cell fate determination during development, in particular, in CNS. The transcriptional activity of several LHX proteins is postulated to be regulated by interaction with an LIM-domain binding protein, Ldb1. We have now identified a novel LHX molecule, termed Lhx6.1, that is closely related to a recently reported Lhx6 molecule. The Lhx6.1 transcript is found in several restricted regions in the developing CNS, mostly within the embryonic forebrain. We further show that Lhx6.1 interacts with Ldb1 through tandem LIM-domains, implying transcriptional regulation of Lhx6.1 by Ldb1.

A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Publishing Authors By Initials

N Kimura,M Ueno,K Nakashima,T Taga,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 126

Page Numbers: 180-7

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jul

YEAR: 1999

A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Information

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LANGUAGE: eng

NlmUniqueID: 376600

A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: metabolism

Chemical & Substance for Abstract: A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains. Information

Substance Name: Recombinant Proteins

Registry Number: 0

Grant and Affiliation Information for A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains.

AFFILIATION: Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 101-0062, Japan.

Country: JAPAN

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MEDLINETA: J Biochem

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ACCESSION NUMBER: AB031042

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