A blood cyanide distribution study in the rabbits intoxicated by oral route and by inhalation.

A blood cyanide distribution study in the rabbits intoxicated by oral route and by inhalation. Research Abstract Details 

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A blood cyanide distribution study in the rabbits intoxicated by oral route and by inhalation. Abstract Text:

K Yamamoto,Y Yamamoto,C Kuwahara,

Blood cyanide concentration was determined in rabbits intoxicated orally or by inhalation. Experiments were carried out under urethane anaesthesia. In the inhalation experiments, rabbits inhaled a combustion product containing HCN via the tracheal cannula and in the oral studies animals were administered NaCN solution into the stomach. In addition to the carotid artery and jugular vein blood samples, postmortem samples were obtained from both sides of the heart and the descending vena cava. The arterial cyanide concentration in the inhalation group showed a close relationship with ventilation. After an initial rise, blood levels decreased a little, in some cases with transient apnea. At the last stage it again increased with gasping, reaching its maximal value. After ultimate apnea, the blood cyanide concentration declined. The blood cyanide values were higher in the oral group than in the inhalation group. The difference between the two groups became larger in the inferior order, the left heart blood--the right heart blood--blood in the descending vena cava. The left heart/right heart ratio of the inhalation group was significantly higher than that of the oral group (1.28+/- 0.28 vs. 0.95+/- 0.09). The coefficient of variation (c.v.) of the inhalation group was larger than that of the other group. Within the inhalation group, the left heart blood showed the largest c.v. values and this was probably due to redistribution of the cyanide by bloodstream after attainment of the maximal concentration.

A blood cyanide distribution study in the rabbits intoxicated by oral route and by inhalation. Publishing Authors By Initials

K Yamamoto,Y Yamamoto,C Kuwahara,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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A blood cyanide distribution study in the rabbits intoxicated by oral route and by inhalation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zeitschrift für Rechtsmedizin. Journal of legal me

VOLUME: 83

Page Numbers: 313-7

Journal Abbreviation: Z. Rechtsmed.

ISSN: 0044-3433

DAY: 20

MONTH: Oct

YEAR: 1979

A blood cyanide distribution study in the rabbits intoxicated by oral route and by inhalation. Information

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LANGUAGE: eng

NlmUniqueID: 247437

A blood cyanide distribution study in the rabbits intoxicated by oral route and by inhalation. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: poisoning

Chemical & Substance for Abstract: A blood cyanide distribution study in the rabbits intoxicated by oral route and by inhalation. Information

Substance Name: Cyanides

Registry Number: 0

Grant and Affiliation Information for A blood cyanide distribution study in the rabbits intoxicated by oral route and by inhalation.

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Country: GERMANY, WEST

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MEDLINETA: Z Rechtsmed

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