A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier.

A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier. Research Abstract Details 

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A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier. Abstract Text:

G Wei,Y Kotoura,M Oka,T Yamamuro,R Wada,S H Hyon,Y Ikada,

We prepared a composite of D,L-lactic acid oligomer and dideoxykanamycin B for use as a biodegradable antibiotic delivery system with sustained effect. The composite was implanted in the distal portion of the rabbit femur, and the effective concentration of the antibiotic was measured in the cortex, the cancellous bone, and the bone marrow. In all bone tissues around the implant, the concentration of antibiotic exceeded the minimum inhibitory concentration for the common causative organisms of osteomyelitis for six weeks. Most of the implant material had been absorbed and the bone marrow had been repaired to a nearly normal state within nine weeks of implantation. The implant caused no systemic side effects, and it is likely to prove clinically useful as a drug delivery system for treating chronic osteomyelitis.

A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier. Publishing Authors By Initials

G Wei,Y Kotoura,M Oka,T Yamamuro,R Wada,SH Hyon,Y Ikada,

For similar animals: chordata: vertebrates: mammals: lagomorpha: rabbits research abstracts see: animals: chordata: vertebrates: mammals: lagomorpha: rabbits research

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A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of bone and joint surgery. British vol

VOLUME: 73

Page Numbers: 246-52

Journal Abbreviation:

ISSN: 0301-620X

DAY: 14

MONTH: Mar

YEAR: 1991

A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier. Information

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LANGUAGE: eng

NlmUniqueID: 375355

A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier. Keywords Mesh Terms:

KEYWORDS: Rabbits

MESH TERMS: pathology

Chemical & Substance for Abstract: A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier. Information

Substance Name: Creatinine

Registry Number: 60-27-5

Grant and Affiliation Information for A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. The use of lactic acid oligomer as a carrier.

AFFILIATION: Research Centre for Medical Polymers and Biomaterials, Kyoto University, Japan.

Country: ENGLAND

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MEDLINETA: J Bone Joint Surg Br

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