A Bayesian analysis of doubly censored data using a hierarchical Cox model.

A Bayesian analysis of doubly censored data using a hierarchical Cox model. Research Abstract Details 

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A Bayesian analysis of doubly censored data using a hierarchical Cox model. Abstract Text:

Wei Zhang,Kathryn Chaloner,Mary Kathryn Cowles,Ying Zhang,Jack T Stapleton,Wei Zhang,Kathryn Chaloner,Mary Kathryn Cowles,Ying Zhang,Jack T Stapleton,

Two common statistical problems in pooling survival data from several studies are addressed. The first problem is that the data are doubly censored in that the origin is interval censored and the endpoint event may be right censored. Two approaches to incorporate the uncertainty of interval-censored origins are developed, and then compared with more usual analyses using imputation of a single fixed value for each origin. The second problem is that the data are collected from multiple studies and it is likely that heterogeneity exists among the study populations. A random-effects hierarchical Cox proportional hazards model is therefore used.The scientific problem motivating this work is a pooled survival analysis of data sets from three studies to examine the effect of GB virus type C (GBV-C) coinfection on survival of HIV-infected individuals. The time of HIV infection is the origin and for each subject this time is unknown, but is known to lie later than the last time at which the subject was known to be HIV negative, and earlier than the first time the subject was known to be HIV positive. The use of an approximate Bayesian approach using the partial likelihood as the likelihood is recommended because it more appropriately incorporates the uncertainty of interval-censored HIV infection times. Copyright (c) 2007 John Wiley & Sons, Ltd.

A Bayesian analysis of doubly censored data using a hierarchical Cox model. Publishing Authors By Initials

W Zhang,K Chaloner,MK Cowles,Y Zhang,JT Stapleton,W Zhang,K Chaloner,MK Cowles,Y Zhang,JT Stapleton,

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A Bayesian analysis of doubly censored data using a hierarchical Cox model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Statistics in medicine

VOLUME: 27

Page Numbers: 529-42

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ISSN: 0277-6715

DAY: 20

MONTH: Feb

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for A Bayesian analysis of doubly censored data using a hierarchical Cox model.

AFFILIATION: Department of Biostatistics, University of Iowa, Iowa City, IA, U.S.A.

Country: England

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MEDLINETA: Stat Med

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