A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates.

A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates. Abstract Text:

Roger Panteri,Alessandro Paiardini,Flavio Keller,

Reelin is a large molecule of the extracellular matrix (ECM) which regulates neuronal positioning during the early stages of cortical development in vertebrate species. The Reelin molecule can be subdivided into a smaller N-terminal domain, showing homology with F-spondin, and a larger C-terminal region containing 8 EGF-like repeats. The localization of Reelin in the ECM, its large dimensions and the modular organization of its primary structure led us to suppose a structure of its modules similar to domains commonly found in ECM proteins such as Agrin, laminins and thrombospondins. We therefore performed a sequence alignment and molecular modeling analysis to study the three-dimensional fold of the Reelin subrepeat regions. Our analysis produces a tentative model of the core region of the Reelin subrepeat sequences and suggests the presence in this 3D model of structural features common to polysaccharide-binding modules which are often found on proteoglycans of the ECM. These findings provide a conceptual framework for further experiments aimed at testing the functions of the EGF-like repeat regions of Reelin.

A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates. Publishing Authors By Initials

R Panteri,A Paiardini,F Keller,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases research

PUBMED ID PMID:

MEDLINE DATE:

A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Brain research

VOLUME: 1116

Page Numbers: 222-30

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 18

MONTH: 09

YEAR: 2006

A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 45503

A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates. Keywords Mesh Terms:

KEYWORDS: Serine Endopeptidases

MESH TERMS: metabolism

Chemical & Substance for Abstract: A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates. Information

Substance Name: reelin protein

Registry Number: EC 3.4.21.-

Grant and Affiliation Information for A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates.

AFFILIATION: Laboratory of Developmental Neuroscience, Università Campus Bio-Medico, Via Longoni 83, 00155 Rome, Italy. R.Panteri@unicampus.it

Country: Netherlands

AGENCY: United States NINDS

GRANT: R01 NS 042616

ACRONYM: NS

MEDLINETA: Brain Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates Related Publications

• A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates.
• Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain.
• Antenatal and postnatal lung and vascular anatomic and functional studies in congenital diaphragmatic hernia: implications for clinical management.
• BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
• Bone morphogenetic protein 2 induces placental growth factor in mesenchymal stem cells.
• Candicine from Stapelia gigantea.
• Children's skin conductance reactivity as a mechanism of risk in the context of parental depressive symptoms.
• Comparison of extracellular and intracellular potency of botulinum neurotoxins.
• Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).
• Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures.
• Drosophila melanogaster's history as a human commensal.
• Effect of glucocorticoid-induced osteoporotic-like conditions on osteoblast cell attachment to implant surface microtopographies.
• Effect of operational parameters on the recovery rate of an oleophilic drum skimmer.
• Flagellar elongation and gene expression in Chlamydomonas reinhardtii.
• GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence.
• Illegitimate recombination is a major evolutionary mechanism for initiating size variation in plant resistance genes.
• Interplay between oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease.
• Metabolic pathway engineering in cotton: Biosynthesis of polyhydroxybutyrate in fiber cells.
• Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages.
• Production of targeted poly(3-hydroxyalkanoates) copolymers by glycogen accumulating organisms using acetate as sole carbon source.
• Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness.
• Reproductive isolation between Pogonomyrmex rugosus and two lineages with genetic caste determination.
• Secondary metabolic gene cluster silencing in Aspergillus nidulans.
• Short telomeres in short-lived males: what are the molecular and evolutionary causes?
• The presumptive floor plate (notoplate) induces behaviors associated with convergent extension in medial but not lateral neural plate cells of Xenopus.
• The role of Wnts in bone metastases.
• The whisking rhythm generator: a novel mammalian network for the generation of movement.
• Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA.
• What impact, if any, has feminism had on science?
• [Extraction of thermolabile compounds with supercritical gases.]