A 10-residue peptide from durum wheat promotes a shift from a Th1-type response toward a Th2-type response in celiac disease.

A 10-residue peptide from durum wheat promotes a shift from a Th1-type response toward a Th2-type response in celiac disease. Research Abstract Details 

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A 10-residue peptide from durum wheat promotes a shift from a Th1-type response toward a Th2-type response in celiac disease. Abstract Text:

Marco Silano,Rita Di Benedetto,Francesca Maialetti,Alessandro De Vincenzi,Roberta Calcaterra,Antonello Trecca,Massimo De Vincenzi,Marco Silano,Rita Di Benedetto,Francesca Maialetti,Alessandro De Vincenzi,Roberta Calcaterra,Antonello Trecca,Massimo De Vincenzi,

BACKGROUND: Celiac disease (CD) is a Th1-driven autoimmune permanent enteropathy that is triggered by dietary gluten. Molecules able to shift the immune response from a Th1- to a Th2-type response have been suggested as therapeutic agents for Th1 autoimmune diseases. OBJECTIVE: We sought to investigate the possibility that a decapeptide from durum wheat (p10mer, QQPQDAVQPF), which was previously shown to prevent the activation of celiac peripheral lymphocytes, may promote a shift from a Th1- to a Th2-type immune response in gluten-specific intestinal T cells of CD patients. DESIGN: Intestinal T lymphocyte lines derived from 8 children with CD were incubated with gliadin peptides both alone and simultaneously with p10mer. Cell proliferation and the production of interferon-gamma and interleukin-10 by these T cells were measured. RESULTS: The incubation of celiac intestinal T cells with deamidated gliadin peptides resulted in a significant (P < 0.008) increase in cell proliferation and interferon-gamma release, whereas the simultaneous exposure to p10mer totally abolished the cell proliferation and cytokine release. Moreover, incubation with p10mer maintained an elevated release of interleukin-10, whereas exposure of the cells to culture medium only did not. The replacement of the residues of aspartic acid in position 5 or those of alanine in position 6 in the sequence of p10mer resulted in peptides with no activity in the activation experiments. CONCLUSION: In vitro, p10mer showed the ability to shift the pathogenic immune response of a CD patient from a Th1- to a Th2-type response.

A 10-residue peptide from durum wheat promotes a shift from a Th1-type response toward a Th2-type response in celiac disease. Publishing Authors By Initials

M Silano,R Di Benedetto,F Maialetti,A De Vincenzi,R Calcaterra,A Trecca,M De Vincenzi,M Silano,R Di Benedetto,F Maialetti,A De Vincenzi,R Calcaterra,A Trecca,M De Vincenzi,

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A 10-residue peptide from durum wheat promotes a shift from a Th1-type response toward a Th2-type response in celiac disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The American journal of clinical nutrition

VOLUME: 87

Page Numbers: 415-23

Journal Abbreviation: Am. J. Clin. Nutr.

ISSN: 0002-9165

DAY: 8

MONTH: Feb

YEAR: 2008

A 10-residue peptide from durum wheat promotes a shift from a Th1-type response toward a Th2-type response in celiac disease. Information

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LANGUAGE: eng

NlmUniqueID: 376027

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AFFILIATION: Division of Food Science, Human Nutrition and Health, Istituto Superiore di Sanità, Rome, Italy.

Country: United States

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MEDLINETA: Am J Clin Nutr

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