99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer.

99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer. Research Abstract Details 

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99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer. Abstract Text:

M S Simms,A C Perkins,M R Price,D P Scholfield,M C Bishop,

OBJECTIVES: To assess whether immunoscintigraphy using a conjugate of the anti-MUC1 monoclonal antibody C595 and 99mTc could be used to target transitional cell bladder cancer after intravenous administration to patients. PATIENTS AND METHODS: Twenty-one patients with invasive or metastatic transitional cell carcinoma were recruited. Patients received 1 mg of C595 labelled with 800 MBq 99mTc followed by imaging at 0.5, 6 and 24 h using a combination of planar and single-photon emission computed tomography. Of these patients, 14 subsequently underwent cystectomy, four underwent radiotherapy and the remaining three had histologically confirmed metastatic disease. The results of immunoscintigraphy were compared with surgical findings and conventional radiology. RESULTS: There were no adverse reactions in any patient. Of the 20 patients who were found to have tumour at the time of the study, positive localization of antibody in tumour was apparent in 16. Of the remaining four patients, false-positive localization of antibody in presumed nodal tissue was detected in two. The remaining scan results were equivocal. In three patients, histologically confirmed pelvic nodal metastases that had not been detected on preoperative computed tomography were identified. CONCLUSION: These early results show the potential of 99mTc-C595 immunoscintigraphy for staging bladder cancer. A larger study is needed to fully evaluate the technique.

99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer. Publishing Authors By Initials

MS Simms,AC Perkins,MR Price,DP Scholfield,MC Bishop,

For similar neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research

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99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: BJU international

VOLUME: 88

Page Numbers: 686-91

Journal Abbreviation: BJU Int.

ISSN: 1464-4096

DAY: 1

MONTH: Nov

YEAR: 2001

99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer. Information

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LANGUAGE: eng

NlmUniqueID: 100886721

99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder Neoplasms

MESH TERMS: radionuclide imaging

Chemical & Substance for Abstract: 99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer. Information

Substance Name: Technetium

Registry Number: 7440-26-8

Grant and Affiliation Information for 99mTechnetium-C595 radioimmunoscintigraphy: a potential staging tool for bladder cancer.

AFFILIATION: Department of Urology, City Hospital Nottingham, UK. msimms@gertrude42.freeserve.co.uk

Country: England

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MEDLINETA: BJU Int

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