8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein. Reaction with some amino acids.

8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein. Reaction with some amino acids. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein. Reaction with some amino acids. Abstract Text:

S Kasai,K Sugimoto,R Miura,T Yamano,K Matsui,

8-Fluoro-8-demethylriboflavin was shown to be a potential active-site-directed reagent for flavoproteins. It reacted with the nucleophiles of N-acetylcysteine (-SH), N-acetyltyrosine (-OH), alpha-N-acetyllysine, and glycine (epsilon- and alpha-NH2, respectively) under fairly mild conditions, and the reaction products were identified. The reactivity of the fluoroflavin was higher than that of 8-chloro-8-demethylriboflavin, which reacted only with the cysteine derivative among the amino acid derivatives used, and whose pseudo first order rate constant at 23 degrees C was 1/23 of that of the fluoroflavin. The reactivity of the fluoroflavin was also estimated by 13C and 19F NMR spectroscopy. The results showed that this compound is more reactive than the chloroflavin.

8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein. Reaction with some amino acids. Publishing Authors By Initials

S Kasai,K Sugimoto,R Miura,T Yamano,K Matsui,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

PUBMED ID PMID:

MEDLINE DATE:

8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein. Reaction with some amino acids. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 93

Page Numbers: 397-402

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 1983

8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein. Reaction with some amino acids. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein. Reaction with some amino acids. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: 8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein. Reaction with some amino acids. Information

Substance Name: Riboflavin

Registry Number: 83-88-5

Grant and Affiliation Information for 8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein. Reaction with some amino acids.

AFFILIATION:

Country: JAPAN

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

8-Fluoro-8-demethylriboflavin as a potential active-site-directed reagent for flavoprotein Reaction with some amino acids Related Publications

• A multicenter analysis of the FIP1L1-alphaPDGFR fusion gene in Japanese idiopathic hypereosinophilic syndrome: an aberrant splicing skipping the alphaPDGFR exon 12.
• A novel mutation in the SPG3A gene (atlastin) in hereditary spastic paraplegia.
• A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism.
• Accurate immobilization of antibody-functionalized peptide nanotubes on protein-patterned arrays by optimizing their ligand-receptor interactions.
• Biofidelity of TRL Legform Impactor and Injury Tolerance of the Human Leg in Lateral Impact.
• Biomimetic and aggregation-driven crystallization route for room-temperature material synthesis: growth of beta-Ga(2)O(3) nanoparticles on peptide assemblies as nanoreactors.
• Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils.
• Chronic myeloid leukemia with a rare variant BCR-ABL translocation: t(9;22;21)(q34;q11.2;q11.2).
• Current issues in pediatric medication adherence.
• Derivative (3)t(3;18)(q27;q21)t(18;16)(q21;?) involving the BCL2 and BCL6 genes in follicular lymphoma with t(3;14;18)(q27;q32;q21).
• Developmentally regulated expression of mil-1 and mil-2, mouse interferon-induced transmembrane protein like genes, during formation and differentiation of primordial germ cells.
• Differences in substrate specificity of C(5)-substituted or C(5)-unsubstituted pyrimidine nucleotides by DNA polymerases from thermophilic bacteria, archaea, and phages.
• Differential chain-length specificities of two isoamylase-type starch-debranching enzymes from developing seeds of kidney bean.
• Effects of diet with or without exercise on leptin and anticoagulation proteins levels in obesity.
• Enhancement patterns and signal-intensity characteristics of small hepatocellular carcinoma in cirrhosis: pathologic basis and diagnostic challenges.
• Estimation of the Type Locality of Hynobius naevius (), a Salamander from Japan (Amphibia: Caudata).
• Fabrication of Au nanowires of uniform length and diameter using a monodisperse and rigid biomolecular template: collagen-like triple helix.
• Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma.
• Immune pathogenesis of sclerosing cholangitis in biliary atresia.
• Improvement of temporal and dynamic subtraction images on abdominal CT using 3D global image matching and nonlinear image warping techniques.
• MR imaging of hepatocellular carcinomas with biliary tumor thrombi.
• Mineralization of semiconductor nanocrystals on peptide-coated bionanotubes and their pH-dependent morphology changes.
• Modeling of the Changes in Heart Rate and Blood Pressure with Characteristic Respiratory Waveform during Surgery under Local Anesthesia.
• Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder.
• Potential utility of telmisartan, an angiotensin II type 1 receptor blocker with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity for the treatment of cardiometabolic disorders.
• Roles of the novel interleukin-12-associated cytokine, interleukin-23, in the regulation of T-cell-mediated immunity.
• Roll-over Detection and Sleep Quality Measurement using a Wearable Sensor.
• Serum resistin concentrations in growth hormone-deficient children during growth hormone replacement therapy.
• [Effect of implant junction on bone growth by X-ray analysis]
• [Ten cases of acute superior mesenteric artery occlusion]