5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system.

5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system. Research Abstract Details 

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5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system. Abstract Text:

Keith A Young,Leigh A Holcomb,Willy L Bonkale,Paul B Hicks,Umar Yazdani,Dwight C German,

BACKGROUND: The 5HTTLPR genetic variant of the serotonin transporter (SERT), which consists of a long (SERT-l) and short (SERT-s) allele, has emerged as a major factor influencing emotional behavior and brain anatomy. The pulvinar nucleus of the thalamus projects to important limbic nuclei including the amygdala and cingulate cortex, is involved in the processing of stimuli with emotional content, and contains an abundance of SERT. METHODS: Stereological methods were used to measure pulvinar neuron number in postmortem tissue from major depressive disorder (n = 11), bipolar disorder (n = 11), schizophrenia (n = 12), and control (n = 15) specimens from the Stanley Foundation Neuropathology Consortium. The effect of SERT genotype on pulvinar volume and neuron number was investigated by using analysis of covariance. RESULTS: Analysis of covariance with diagnosis, SERT genotype, age, hemisphere, postmortem interval, and time-in-formalin covariates identified a 20% increase in pulvinar neuron number and volume in SERT-ss subjects. CONCLUSIONS: The elevated number of pulvinar neurons in subjects with a SERT-ss genotype may serve to enhance subcortical input of emotionally relevant stimuli to the limbic system, providing a mechanism for the 5HTTLPR genetic variant to affect predisposition to conditions such as major depression.

5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system. Publishing Authors By Initials

KA Young,LA Holcomb,WL Bonkale,PB Hicks,U Yazdani,DC German,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biological psychiatry

VOLUME: 61

Page Numbers: 813-8

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 2

MONTH: 11

YEAR: 2006

5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system. Information

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LANGUAGE: eng

NlmUniqueID: 213264

5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: 5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system. Information

Substance Name: Serotonin Plasma Membrane Transport Prot

Registry Number: 0

Grant and Affiliation Information for 5HTTLPR polymorphism and enlargement of the pulvinar: unlocking the backdoor to the limbic system.

AFFILIATION: Neuropsychiatry Research Program, Central Texas Veterans Health Care System, Temple, Texas 76504, USA. kayoung@medicine.tamhsc.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH59145

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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