5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine.

5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Research Abstract Details 

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5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Abstract Text:

Sabiha K Barot,Susan M Ferguson,John F Neumaier,

Whether serotonin-1B (5-HT(1B)) receptor activation enhances or diminishes the reinforcing properties of psychostimulants remains unclear. We have previously shown that increased expression of 5-HT(1B) receptors in nucleus accumbens (NAcc) shell neurons sensitized rats to the locomotor-stimulating and rewarding properties of cocaine. In this study we further examined the contribution of 5-HT(1B) receptors on the effect of cocaine under conditions intended to selectively influence either conditioned place preference or avoidance (CPP or CPA, respectively). Viral-mediated gene transfer techniques were used to overexpress 5-HT(1B) receptors in medial NAcc shell medium spiny neurons projecting to the ventral tegmental area. Animals were then conditioned to associate place cues with the effects of either a low (5 mg/kg) or moderately high (20 mg/kg) dosage of cocaine immediately or 45 min after intraperitoneal cocaine administration. Animals with increased 5-HT(1B) expression showed cocaine-induced CPP immediately after administration of the low 5 mg/kg dose of cocaine, but a CPA 45 min after administration of the high 20 mg/kg dose. Control animals showed no preference at the 5 mg/kg dose and a significant preference at 20 mg/kg. Given this, we believe that increased 5-HT(1B) receptor activation in NAcc shell projection neurons intensifies both the rewarding and negative properties of cocaine use.

5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Publishing Authors By Initials

SK Barot,SM Ferguson,JF Neumaier,

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The European journal of neuroscience

VOLUME: 25

Page Numbers: 3125-31

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 17

MONTH: 05

YEAR: 2007

5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Information

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LANGUAGE: eng

NlmUniqueID: 8918110

5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: physiology

Chemical & Substance for Abstract: 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Information

Substance Name: Serotonin

Registry Number: 50-67-9

Grant and Affiliation Information for 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine.

AFFILIATION: Program of Neurobiology and Behavior, Department of Psychology, Box 351525, University of Washington, Seattle, WA 98195, USA.

Country: France

AGENCY: United States NIDA

GRANT: DA210090

ACRONYM: DA

MEDLINETA: Eur J Neurosci

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