5-HT excites globus pallidus neurons by multiple receptor mechanisms.

5-HT excites globus pallidus neurons by multiple receptor mechanisms. Research Abstract Details 

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5-HT excites globus pallidus neurons by multiple receptor mechanisms. Abstract Text:

L Chen,K K L Yung,Y S Chan,W H Yung,

Anatomical and neurochemical studies indicated that the globus pallidus receives serotonergic innervation from raphe nuclei but the membrane effects of 5-HT on globus pallidus neurons are not entirely clear. We address this question by applying whole-cell patch-clamp recordings on globus pallidus neurons in immature rat brain slices. Under current-clamp recording, 5-HT depolarized globus pallidus neurons and increased their firing rate, an action blocked by both 5-HT(4) and 5-HT(7) receptor antagonists and attributable to an increase in cation conductance(s). Further experiments indicated that 5-HT enhanced the hyperpolarization-activated inward conductance which is blocked by 5-HT(7) receptor antagonist. To determine if 5-HT exerts any presynaptic effects on GABAergic and glutamatergic inputs, the actions of 5-HT on synaptic currents were studied. At 10 muM, 5-HT increased the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) but had no effect on both the frequency and amplitude of miniature inhibitory postsynaptic currents (mIPSCs). However, 5-HT at a higher concentration (50 muM) decreased the frequency but not the amplitude of the mIPSCs, indicating an inhibition of GABA release from the presynaptic terminals. This effect was sensitive to 5-HT(1B) receptor antagonist. In addition to the presynaptic effects on GABAergic neurotransmission, 5-HT at 50 muM had no consistent effects on glutamatergic neurotransmission, significantly increased the frequency of miniature excitatory postsynaptic currents (mEPSCs) in 4 of 11 neurons and decreased the frequency of mEPSCs in 3 of 11 neurons. In conclusion, we found that 5-HT could modulate the excitability of globus pallidus neurons by both pre- and post-synaptic mechanisms. In view of the extensive innervation by globus pallidus neurons on other basal ganglia nuclei, this action of 5-HT originated from the raphe may have a profound effect on the operation of the entire basal ganglia network.

5-HT excites globus pallidus neurons by multiple receptor mechanisms. Publishing Authors By Initials

L Chen,KK Yung,YS Chan,WH Yung,

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5-HT excites globus pallidus neurons by multiple receptor mechanisms. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroscience

VOLUME: 151

Page Numbers: 439-51

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 7

MONTH: 11

YEAR: 2007

5-HT excites globus pallidus neurons by multiple receptor mechanisms. Information

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LANGUAGE: eng

NlmUniqueID: 7605074

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Grant and Affiliation Information for 5-HT excites globus pallidus neurons by multiple receptor mechanisms.

AFFILIATION: Department of Physiology, The Chinese University of Hong Kong, Shatin, Hong Kong, China; Department of Physiology, Qingdao University, Qingdao, China.

Country: United States

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MEDLINETA: Neuroscience

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