5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study.

5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study. Abstract Text:

J P Obrecht,W Weber,J P Cano,C Crevoisier,P Alberto,I Forgo,R Heintz,G H Germano,

Until now it was unknown, whether 5-fluorouracil (5-FU) would be absorbed sufficiently after oral application, so that therapeutical effects could be expected. For this reason a comparative pharmacokinetic study of intravenous versus oral application was performed on six patients, as well as a pilot study on 13 patients with adenocarcinomas of different origins. The results show that 5-FU is absorbed rapidly. The biological availability increases with higher dose, which would indicate a saturation of the "first pass" in the liver. The clinical study shows partial remission in seven patients, with hepatoma and tolerable signs of bone marrow depression, decrease of hemoglobin, leukocytes and platelets after oral application of 5-FU in doses of 1,000-1,250 mg on days 1, 3, 5, 8, 10, and 12. 5-FU can therefore be given successfully at an adequate dose by the oral route.

5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study. Publishing Authors By Initials

JP Obrecht,W Weber,JP Cano,C Crevoisier,P Alberto,I Forgo,R Heintz,GH Germano,

For similar neoplasms research abstracts see: neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 79

Page Numbers: 101-7

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1981

5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 44671

5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study. Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: drug therapy

Chemical & Substance for Abstract: 5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study. Information

Substance Name: Fluorouracil

Registry Number: 51-21-8

Grant and Affiliation Information for 5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study.

AFFILIATION:

Country: GERMANY, WEST

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Recent Results Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study Related Publications

• 5-Fluorouracil: a comparative pharmacokinetic study and preliminary results of a clinical phase I study.
• Applications and software techniques for integrated cardiac multimodality imaging.
• Chemical composition and antimicrobial activity of Momordica charantia seed essential oil.
• Chemotherapy with gemcitabine and oxaliplatin in patients with advanced biliary tract cancer: a single-institution experience.
• Dermatosis from resorcinal in tyre makers.
• Ehrenfest urn revisited: playing the game on a realistic fluid model.
• Monte Carlo simulation of uncoupled continuous-time random walks yielding a stochastic solution of the space-time fractional diffusion equation.
• Quantitative myocardial-perfusion SPECT: Comparison of three state-of-the-art software packages.
• The 'Memory of Water': an almost deciphered enigma. Dissipative structures in extremely dilute aqueous solutions.
• [C-REACTIVE PROTEIN IN ALLERGIC SKIN DISEASES DUE TO CEMENT DUST.]
• [Construction of knowledge in odontology: the scientific production in debate]
• [ERYTHROCYTE-DAMAGING EFFECT OF THE PESTICIDES AS AN INDEX OF THEIR GENERAL TOXICITY.]
• [Hand-arm vibration syndrome and upper limbs diseases in the forest workers of Italia meridionale]
• [Hepatic function in pneumoconiosis liparotica]
• [Teaching learning process on the nursing laboratory: students' points of view]