3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion.

3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion. Abstract Text:

Karen Beckett,Mary K Baylies,Karen Beckett,Mary K Baylies,

Formation of the Drosophila larval body wall muscles requires the specification, coordinated cellular behaviors and fusion of two cell types: Founder Cells (FCs) that control the identity of the individual muscle and Fusion Competent Myoblasts (FCMs) that provide mass. These two cell types come together to control the final size, shape and attachment of individual muscles. However, the spatial arrangement of these cells over time, the sequence of fusion events and the contribution of these cellular relationships to the fusion process have not been addressed. We analyzed the three-dimensional arrangements of FCs and FCMs over the course of myoblast fusion and assayed whether these issues impact the process of myoblast fusion. We examined the timing of the fusion process by analyzing the fusion profile of individual muscles in wild type and fusion mutants. We showed that there are two temporal phases of myoblast fusion in wild type embryos. Limited fusion events occur during the first 3 h of fusion, while the majority of fusion events occur in the remaining 2.5 h. Altogether, our data have led us to propose a new model of myoblast fusion where the frequency of myoblast fusion events may be influenced by the spatial arrangements of FCs and FCMs.

3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion. Publishing Authors By Initials

K Beckett,MK Baylies,K Beckett,MK Baylies,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 309

Page Numbers: 113-25

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 6

MONTH: 07

YEAR: 2007

3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372762

3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: 3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for 3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion.

AFFILIATION: Program in Developmental Biology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM78318

ACRONYM: GM

MEDLINETA: Dev Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion Related Publications

• 3D analysis of founder cell and fusion competent myoblast arrangements outlines a new model of myoblast fusion.
• Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesis.
• Delivery of wingless to the ventral mesoderm by the developing central nervous system ensures proper patterning of individual slouch-positive muscle progenitors.
• Expression and functional analysis of a novel Fusion Competent Myoblast specific GAL4 driver.
• Influence of progesterone upon the fertility of gonadotrophin-treated female rabbits.
• Myoblast fusion in fly and vertebrates: new genes, new processes and new perspectives.
• Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster.
• SCAR/WAVE and Arp2/3 are crucial for cytoskeletal remodeling at the site of myoblast fusion.
• Serpent and a hibris reporter are co-expressed in migrating cells during Drosophila hematopoiesis and Malpighian tubule formation.
• Specification of individual Slouch muscle progenitors in Drosophila requires sequential Wingless signaling.
• The development of the Drosophila larval body wall muscles.
• Visualizing new dimensions in Drosophila myoblast fusion.