3,4-dichloropropionaniline suppresses normal macrophage function.

3,4-dichloropropionaniline suppresses normal macrophage function. Research Abstract Details 

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3,4-dichloropropionaniline suppresses normal macrophage function. Abstract Text:

Irina V Ustyugova,Laura L Frost,Knox Van Dyke,Kathleen M Brundage,Rosana Schafer,John B Barnett,

Macrophages are a critical part of the innate immune response and natural surveillance mechanisms. As such, proper macrophage function is crucial for engulfing bacterial pathogens through phagocytosis and destroying them by generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). The production of a number of cytokines by macrophages, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6, plays an important role in the initiation of the acquired immune response creating an inflammatory environment favorable for fighting a bacterial infection. 3,4-Dichloropropionaniline (DCPA) suppresses several inflammatory parameters, including TNF-alpha production through a mechanism where nuclear factor-kappaB (NF-kappaB)-DNA binding is inhibited but not entirely abrogated. The goal of the present study was to evaluate the effects of DCPA on the inflammatory mediators of macrophages, including ROS and RNS in both murine peritoneal exudate cells and the human monocytic cell line, THP-1. The ability to perform phagocytosis and directly kill Listeria monocytogenes was also assessed. The results indicate that DCPA decreases the ability of both types of macrophages to phagocytize beads and generate both types of reactive species, which was correlated with a decrement in listericidal activity. These results demonstrate that DCPA has profound effects on macrophage function and provide insight into the potential mechanisms of immunosuppression by DCPA.

3,4-dichloropropionaniline suppresses normal macrophage function. Publishing Authors By Initials

IV Ustyugova,LL Frost,K Van Dyke,KM Brundage,R Schafer,JB Barnett,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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3,4-dichloropropionaniline suppresses normal macrophage function. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Toxicological sciences : an official journal of th

VOLUME: 97

Page Numbers: 364-74

Journal Abbreviation: Toxicol. Sci.

ISSN: 1096-6080

DAY: 12

MONTH: 03

YEAR: 2007

3,4-dichloropropionaniline suppresses normal macrophage function. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9805461

3,4-dichloropropionaniline suppresses normal macrophage function. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: metabolism

Chemical & Substance for Abstract: 3,4-dichloropropionaniline suppresses normal macrophage function. Information

Substance Name: Nitric Oxide Synthase Type II

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for 3,4-dichloropropionaniline suppresses normal macrophage function.

AFFILIATION: Department of Microbiology, Immunology and Cell Biology, Center for Immunopathology and Microbial Pathogenesis, West Virginia University, Morgantown, WV 26506-9177, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: ES07512

ACRONYM: ES

MEDLINETA: Toxicol Sci

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