3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1.

3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1. Research Abstract Details 

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3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1. Abstract Text:

Shinnosuke Hosoda,Yuichi Hashimoto,

We designed and synthesized novel type 1 5alpha-reductase inhibitors by using 3,3-diphenylpentane skeleton as a substitute for the usual steroid skeleton. 4-(3-(4-(N-Methylacetamido)phenyl)pentan-3-yl)phenyl dibenzylcarbamate (11k) is a competitive 5alpha-reductase inhibitor with the IC(50) value of 0.84 microM.

3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1. Publishing Authors By Initials

S Hosoda,Y Hashimoto,

For similar enzymes and coenzymes: enzymes: oxidoreductases: oxidoreductases acting on ch-ch group donors: testosterone 5-alpha-reductase research abstracts see: enzymes and coenzymes: enzymes: oxidoreductases: oxidoreductases acting on ch-ch group donors: testosterone 5-alpha-reductase research

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3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5414-8

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 31

MONTH: 07

YEAR: 2007

3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1. Keywords Mesh Terms:

KEYWORDS: Testosterone 5-alpha-Reductase

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: 3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1. Information

Substance Name: Testosterone 5-alpha-Reductase

Registry Number: EC 1.3.99.5

Grant and Affiliation Information for 3,3-diphenylpentane skeleton as a steroid skeleton substitute: novel inhibitors of human 5alpha-reductase 1.

AFFILIATION: Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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