3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis.

3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Research Abstract Details 

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3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Abstract Text:

Tomoko Hayashi,Ji-Hun Mo,Xing Gong,Cyprian Rossetto,Angela Jang,Lucinda Beck,Gregory I Elliott,Irina Kufareva,Ruben Abagyan,David H Broide,Jongdae Lee,Eyal Raz,Tomoko Hayashi,Ji-Hun Mo,Xing Gong,Cyprian Rossetto,Angela Jang,Lucinda Beck,Gregory I Elliott,Irina Kufareva,Ruben Abagyan,David H Broide,Jongdae Lee,Eyal Raz,

3-Hydroxyanthranilic acid (HAA), a compound generated during tryptophan metabolism initiated by indoleamine 2,3-dioxygenase, is known to induce T cell death, but its molecular target is not known. Here we report that HAA inhibits NF-kappaB activation upon T cell antigen receptor engagement by specifically targeting PDK1. Inhibition of NF-kappaB by HAA leads to dysfunction and cell death of activated Th2 cells, which in turn suppresses experimental asthma. Inhibition of NF-kappaB and induction of apoptosis is specific to CD4 T cells because HAA does not inhibit NF-kappaB activation or induce cell death upon Toll-like receptor 4 stimulation in dendritic cells. Thus, HAA is a natural inhibitor that restrains T cell expansion and activation.

3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Publishing Authors By Initials

T Hayashi,JH Mo,X Gong,C Rossetto,A Jang,L Beck,GI Elliott,I Kufareva,R Abagyan,DH Broide,J Lee,E Raz,T Hayashi,JH Mo,X Gong,C Rossetto,A Jang,L Beck,GI Elliott,I Kufareva,R Abagyan,DH Broide,J Lee,E Raz,

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3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 18619-24

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 14

MONTH: 11

YEAR: 2007

3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for 3-Hydroxyanthranilic acid inhibits PDK1 activation and suppresses experimental asthma by inducing T cell apoptosis.

AFFILIATION: Department of Medicine, University of California at San Diego, La Jolla, CA 92093-0663, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL79449

ACRONYM: HL

MEDLINETA: Proc Natl Acad Sci U S A

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