(2S,2'R)-analogue of LG190178 is a major active isomer.

(2S,2'R)-analogue of LG190178 is a major active isomer. Research Abstract Details 

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(2S,2'R)-analogue of LG190178 is a major active isomer. Abstract Text:

Wataru Hakamata,Yukiko Sato,Haruhiro Okuda,Shinobu Honzawa,Nozomi Saito,Seishi Kishimoto,Atsushi Yamashita,Takayuki Sugiura,Atsushi Kittaka,Masaaki Kurihara,Wataru Hakamata,Yukiko Sato,Haruhiro Okuda,Shinobu Honzawa,Nozomi Saito,Seishi Kishimoto,Atsushi Yamashita,Takayuki Sugiura,Atsushi Kittaka,Masaaki Kurihara,

Vitamin D receptor (VDR) ligands are therapeutic agents for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism. VDR ligands also show immense potential as therapeutic agents for autoimmune diseases and cancers of the skin, prostate, colon, and breast as well as leukemia. LG190178 is a novel non-secosteroidal ligand for VDR. We synthesized and evaluated stereoisomers of LG190178 and found that only an (2S,2'R)-analogue of LG190178 (YR301) had strong activity.

(2S,2'R)-analogue of LG190178 is a major active isomer. Publishing Authors By Initials

W Hakamata,Y Sato,H Okuda,S Honzawa,N Saito,S Kishimoto,A Yamashita,T Sugiura,A Kittaka,M Kurihara,W Hakamata,Y Sato,H Okuda,S Honzawa,N Saito,S Kishimoto,A Yamashita,T Sugiura,A Kittaka,M Kurihara,

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(2S,2'R)-analogue of LG190178 is a major active isomer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 120-3

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 1464-3405

DAY: 5

MONTH: 11

YEAR: 2007

(2S,2'R)-analogue of LG190178 is a major active isomer. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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AFFILIATION: Division of Organic Chemistry, National Institute of Health Sciences, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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