2B4 functions as a co-receptor in human NK cell activation.

2B4 functions as a co-receptor in human NK cell activation. Research Abstract Details 

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2B4 functions as a co-receptor in human NK cell activation. Abstract Text:

Natural cytotoxicity receptors (NKp46, NKp44 and NKp300) play a predominant role in human NK cell triggering during natural cytotoxicity. Human 2B4 also induced NK cell activation in redirected killing assays using anti-2B4 monoclonal antibodies (mAb) and murine targets. Since this effect was confined to a fraction of NK cells, this suggested a functional heterogeneity of 2B4 molecules. Here we show that activation via 2B4 in redirected killing against murine targets is strictly dependent upon the engagement of NKp46 by murine ligand (s) on target cells. Thus, NK cell clones expressing high surface density of NKp46 (NKp46bright) were triggered by anti-2B4 mAb, whereas NKp46dull clones were not although they expressed a comparable surface density of 2B4. mAb-mediated modulation of NKp46 molecules in NKp46bright clones had no effect on the expression of 2B4 while it rendered cells unresponsive to anti-2B4 mAb. Finally, anti-2B4 mAb could induce NK cell triggering in NKp46dull clones provided that suboptimal doses of anti-NKp44 or anti-CD16 mAb were added to the redirected killing assay. These results indicate that differences in responses do not reflect a functional heterogeneity of 2B4 but rather depend on the co-engagement of triggering receptors.

2B4 functions as a co-receptor in human NK cell activation. Publishing Authors By Initials

For similar investigative techniques: genetic techniques: gene transfer techniques: transfection research abstracts see: investigative techniques: genetic techniques: gene transfer techniques: transfection research

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2B4 functions as a co-receptor in human NK cell activation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of immunology

VOLUME: 30

Page Numbers: 787-93

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 26

MONTH: Mar

YEAR: 2000

2B4 functions as a co-receptor in human NK cell activation. Information

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LANGUAGE: eng

NlmUniqueID: 1273201

2B4 functions as a co-receptor in human NK cell activation. Keywords Mesh Terms:

KEYWORDS: Transfection

MESH TERMS: metabolism

Chemical & Substance for Abstract: 2B4 functions as a co-receptor in human NK cell activation. Information

Substance Name: Receptors, Immunologic

Registry Number: 0

Grant and Affiliation Information for 2B4 functions as a co-receptor in human NK cell activation.

AFFILIATION: Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, Italy.

Country: GERMANY

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MEDLINETA: Eur J Immunol

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