2006 Curt P. Richter award winner: Social influences on stress responses and health.

2006 Curt P. Richter award winner: Social influences on stress responses and health. Research Abstract Details 

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2006 Curt P. Richter award winner: Social influences on stress responses and health. Abstract Text:

A Courtney DeVries,Tara K S Craft,Erica R Glasper,Gretchen N Neigh,Jessica K Alexander,

Both positive and negative social interactions can modulate the hypothalamic-pituitary-adrenal (HPA) axis and influence recovery from injuries and illnesses, such as wounds, stroke, and cardiac arrest. Stress exacerbates neuronal death following stroke and cardiac arrest, and delays cutaneous wound healing, via a common mechanism involving stress-induced increases in corticosterone, acting on glucocorticoid receptors. In contrast, hamsters and mice that form social bonds are buffered against stress and heal cutaneous wounds more quickly than socially isolated animals, presumably because the physical contact experienced by the pairs releases oxytocin, which in turn suppresses the HPA axis and facilitates wound healing. Social housing also decreases stroke-induced neuronal death and improves functional recovery, but the mechanism appears to involve suppressing the inflammatory response that accompanies stroke, rather than alterations in HPA axis activity. An interaction between the HPA axis and immune system determines stroke outcome in neonatally manipulated mice that exhibit life-long dampening of the HPA axis. Taken together, these studies provide support for the detrimental effects of stress and identify potential mechanisms underlying the well-documented clinical observation that social support positively influences human health.

2006 Curt P. Richter award winner: Social influences on stress responses and health. Publishing Authors By Initials

AC DeVries,TK Craft,ER Glasper,GN Neigh,JK Alexander,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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2006 Curt P. Richter award winner: Social influences on stress responses and health. Journal Published:

PUBLICATION TYPE: Review

Journal: Psychoneuroendocrinology

VOLUME: 32

Page Numbers: 587-603

Journal Abbreviation: Psychoneuroendocrinology

ISSN: 0306-4530

DAY: 21

MONTH: 06

YEAR: 2007

2006 Curt P. Richter award winner: Social influences on stress responses and health. Information

Number of References: 185

LANGUAGE: eng

NlmUniqueID: 7612148

2006 Curt P. Richter award winner: Social influences on stress responses and health. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: physiology

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Grant and Affiliation Information for 2006 Curt P. Richter award winner: Social influences on stress responses and health.

AFFILIATION: Department of Psychology and Neuroscience, The Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH 43210, USA. devries.14@osu.edu

Country: England

AGENCY: United States NHLBI

GRANT: R01HL080249-01

ACRONYM: HL

MEDLINETA: Psychoneuroendocrinology

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