2'-O-methyl modification in mouse piRNAs and its methylase.

2'-O-methyl modification in mouse piRNAs and its methylase. Research Abstract Details 

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2'-O-methyl modification in mouse piRNAs and its methylase. Abstract Text:

Yohei Kirino,Zissimos Mourelatos,

Piwi-interacting RNAs (piRNAs) are a novel class of small regulatory RNAs that are expressed specifically and abundantly in germ cells. Mammalian piRNAs are 26 approximately 31 nucleotides (nt) in length and bind to Piwi proteins, but their function and biogenesis remain elusive. Here we report that the 3'-termini of mouse piRNAs are 2'-O-methylated. Furthermore, the mouse homolog of HEN1, a plant microRNA (miRNA) 2'-O-methyltransferase, is expressed specifically in testis and methylates 3'-termini of piRNAs in vitro. These findings provide insight into the biogenesis of piRNAs.

2'-O-methyl modification in mouse piRNAs and its methylase. Publishing Authors By Initials

Y Kirino,Z Mourelatos,

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2'-O-methyl modification in mouse piRNAs and its methylase. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nucleic acids symposium series (2004)

VOLUME:

Page Numbers: 417-8

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

2'-O-methyl modification in mouse piRNAs and its methylase. Information

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LANGUAGE: eng

NlmUniqueID: 101259965

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Grant and Affiliation Information for 2'-O-methyl modification in mouse piRNAs and its methylase.

AFFILIATION: Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Country: England

AGENCY: United States NICHD

GRANT: P30-HD026979

ACRONYM: HD

MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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