[2-hydroxy-methyl-1(N-phtaloyltryptophyl) aziridine stimulates in vitro humain lymphocyte proliferation and interleukin secretion.]

[2-hydroxy-methyl-1(N-phtaloyltryptophyl) aziridine stimulates in vitro humain lymphocyte proliferation and interleukin secretion.] Research Abstract Details 

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[2-hydroxy-methyl-1(N-phtaloyltryptophyl) aziridine stimulates in vitro humain lymphocyte proliferation and interleukin secretion.] Abstract Text:

AIM OF THIS WORK: Aziridines have been shown to possess marked immunotropic activity. In this study, the in vitro effects of a new aziridine, 2-hydroxy-methyl-1-(N-phtaloyltryptophyl) aziridine, were determined on the proliferative responses of human lymphocytes stimulated by mitogens and on interleukin (IL-2, IL-6) secretion. MATERIAL AND METHODS: Peripheral blood lymphocytes were isolated using differential centrifugation on a density gradient of Ficoll-Paque. They were cultured with or without mitogens (Concanavalin A and lipopolysaccharide), and with different concentrations of the aziridine. Proliferation was monitored by direct cell counts and confirmed by MTT [3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay. After different incubations, IL-2 and IL-6 were determined by using commercially avaible Elisa kits. RESULTS: The aziridine tested significantly stimulated the resting and mitogen T and B lymphocyte proliferation at concentrations between 1 muM and 1 mM, in a dose-dependent manner. It also increased IL-2 and IL-6 secretion. CONCLUSION: 2-hydroxy-methyl-1-(N-phtaloyltryptophyl) aziridine displayed immunomodulatory properties and is potentially immunostimulant. It could be used to provide non-specific cell-mediated immune responses.

[2-hydroxy-methyl-1(N-phtaloyltryptophyl) aziridine stimulates in vitro humain lymphocyte proliferation and interleukin secretion.] Publishing Authors By Initials

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[2-hydroxy-methyl-1(N-phtaloyltryptophyl) aziridine stimulates in vitro humain lymphocyte proliferation and interleukin secretion.] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pathologie-biologie

VOLUME: 56

Page Numbers: 137-42

Journal Abbreviation: Pathol. Biol.

ISSN: 0369-8114

DAY: 3

MONTH: 07

YEAR: 2007

[2-hydroxy-methyl-1(N-phtaloyltryptophyl) aziridine stimulates in vitro humain lymphocyte proliferation and interleukin secretion.] Information

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LANGUAGE: fre

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AFFILIATION: Laboratoire de physiologie animale et biochimie, département de biologie, faculté des sciences, université Abou-Bekr-Belkaid, BP 119, Imama, 13000 Tlemcen, Algérie.

Country: France

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MEDLINETA: Pathol Biol (Paris)

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