2-Deoxy-D-glucose-induced central glycopenia differentially influences renal and adrenal nerve activity in awake SHR rats.

2-Deoxy-D-glucose-induced central glycopenia differentially influences renal and adrenal nerve activity in awake SHR rats. Research Abstract Details 

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2-Deoxy-D-glucose-induced central glycopenia differentially influences renal and adrenal nerve activity in awake SHR rats. Abstract Text:

O S Medvedev,M Delle,P Thoren,

2-deoxy-D-glucose (2-DG) evokes an increase in the efferent discharge rate of the adrenal nerve in narcotized rats and rabbits. The study reported here was undertaken to determine the sympathetic nerves and blood pressure responses to i.v. 2-DG administration in awake SHR rats. An increase in adrenal sympathetic nerve activity (adrSNA) by 63% was observed 15 min after 125 mg/kg 2-DG administration, but there were no changes in the renal sympathetic nerve activity (renSNA), blood pressure (BP) or the heart rate (HR). Additional administration of 375 mg/kg 2-DG (cumulative dose was 500 mg/kg) led to the increase in the adrSNA by more then 120%, and in BP by 20 mm Hg, whereas renSNA was increased only by 30%. These results indicate that 2-DG-induced neuroglycopenia evokes highly differential changes in adrenal and renSNA in awake SHR rats. Whether this explains the marked response in BP in SHR to 2-DG is to be established.

2-Deoxy-D-glucose-induced central glycopenia differentially influences renal and adrenal nerve activity in awake SHR rats. Publishing Authors By Initials

OS Medvedev,M Delle,P Thoren,

For similar nervous system: peripheral nervous system: autonomic nervous system: sympathetic nervous system research abstracts see: nervous system: peripheral nervous system: autonomic nervous system: sympathetic nervous system research

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2-Deoxy-D-glucose-induced central glycopenia differentially influences renal and adrenal nerve activity in awake SHR rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 10 Suppl 1

Page Numbers: 375-81

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1988

2-Deoxy-D-glucose-induced central glycopenia differentially influences renal and adrenal nerve activity in awake SHR rats. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

2-Deoxy-D-glucose-induced central glycopenia differentially influences renal and adrenal nerve activity in awake SHR rats. Keywords Mesh Terms:

KEYWORDS: Sympathetic Nervous System

MESH TERMS: physiology

Chemical & Substance for Abstract: 2-Deoxy-D-glucose-induced central glycopenia differentially influences renal and adrenal nerve activity in awake SHR rats. Information

Substance Name: Deoxyglucose

Registry Number: 154-17-6

Grant and Affiliation Information for 2-Deoxy-D-glucose-induced central glycopenia differentially influences renal and adrenal nerve activity in awake SHR rats.

AFFILIATION: All-Union Cardiology Research Center, Moscow, USSR.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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