1H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine.

1H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine. Research Abstract Details 

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1H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine. Abstract Text:

Haiwei Gu,Zhengzheng Pan,Chester Duda,Doug Mann,Candice Kissinger,Candace Rohde,Daniel Raftery,

Nuclear magnetic resonance (NMR) spectroscopy was used to evaluate and optimize the strategy for collecting mouse urine samples. A series of normal urine samples and those mixed with folate-deficient food, turkey or mouse fecal particles were analyzed using principal component analysis (PCA). The metabolic profile of urine mixed with folate-deficient food was found to be extremely different than that of clean urine. Changes in the urine composition caused by mixing with turkey or feces are relatively small as judged by the output of PCA. As a result, turkey may be considered as an applicable food source for obtaining uncontaminated urine samples for metabolomics-based research.

1H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine. Publishing Authors By Initials

H Gu,Z Pan,C Duda,D Mann,C Kissinger,C Rohde,D Raftery,

For similar fluids and secretions: body fluids: urine research abstracts see: fluids and secretions: body fluids: urine research

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1H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 45

Page Numbers: 134-40

Journal Abbreviation:

ISSN: 0731-7085

DAY: 10

MONTH: 07

YEAR: 2007

1H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine. Information

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LANGUAGE: eng

NlmUniqueID: 8309336

1H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine. Keywords Mesh Terms:

KEYWORDS: Urine

MESH TERMS: chemistry

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Grant and Affiliation Information for 1H NMR study of the effects of sample contamination in the metabolomic analysis of mouse urine.

AFFILIATION: Department of Physics, Purdue University, 525 Northwestern Avenue, West Lafayette, IN 47907, USA.

Country: England

AGENCY: United States NIDDK

GRANT: 3 R21 DK070290-01

ACRONYM: DK

MEDLINETA: J Pharm Biomed Anal

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