(18)F-Fluorodeoxyglucose-positron emission tomography and bone scintigraphy for detecting bone metastases in patients with malignancies of the upper aerodigestive tract.

(18)F-Fluorodeoxyglucose-positron emission tomography and bone scintigraphy for detecting bone metastases in patients with malignancies of the upper aerodigestive tract. Research Abstract Details 

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(18)F-Fluorodeoxyglucose-positron emission tomography and bone scintigraphy for detecting bone metastases in patients with malignancies of the upper aerodigestive tract. Abstract Text:

Mi Ra Kim,Jong-Lyel Roh,Jae Seung Kim,Seung-Ho Choi,Soon Yuhl Nam,Sang Yoon Kim,Mi Ra Kim,Jong-Lyel Roh,Jae Seung Kim,Seung-Ho Choi,Soon Yuhl Nam,Sang Yoon Kim,

The role of (18)F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) in identifying bone metastases in patients with head and neck cancer is not clear. We compared the ability of FDG-PET and bone scintigraphy (BS) to detect bone metastases in patients with upper aerodigestive tract (UADT) malignancies. Patients with histologically confirmed malignancies in the UADT underwent both FDG-PET and BS at initial staging or follow-up. The two methods were compared in patients and in seven skeletal regions. Maximum standard uptake value (SUVmax) on PET was calculated in each lesion and compared between true- and false-positive lesions. This study included 564 eligible patients, of whom 17 had bone metastases. The spine was the most frequently involved site, followed by the lungs and liver. Both FDG-PET and BS had high specificity, accuracy, and negative predictive values for detecting bone metastases (>95% each), and the two methods did not differ in sensitivity, specificity, and predictive values (P>0.05). Both FDG-PET (n=15) and BS (n=14) yielded a significant number of false-positive results, which could be corrected by further work-ups and follow-up imaging. Compared with true-positive lesions, the false-positive lesions on FDG-PET were usually single (86.7% vs. 12.5%, P<0.001) and had lower mean SUVmax (2.4 vs. 5.6, P<0.001). FDG-PET is not more accurate than BS for detecting bone metastasis in patients with UADT cancer. Positive findings on FDG-PET or BS require further confirmation.

(18)F-Fluorodeoxyglucose-positron emission tomography and bone scintigraphy for detecting bone metastases in patients with malignancies of the upper aerodigestive tract. Publishing Authors By Initials

MR Kim,JL Roh,JS Kim,SH Choi,SY Nam,SY Kim,MR Kim,JL Roh,JS Kim,SH Choi,SY Nam,SY Kim,

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(18)F-Fluorodeoxyglucose-positron emission tomography and bone scintigraphy for detecting bone metastases in patients with malignancies of the upper aerodigestive tract. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oral oncology

VOLUME: 44

Page Numbers: 148-52

Journal Abbreviation: Oral Oncol.

ISSN: 1368-8375

DAY: 12

MONTH: 03

YEAR: 2007

(18)F-Fluorodeoxyglucose-positron emission tomography and bone scintigraphy for detecting bone metastases in patients with malignancies of the upper aerodigestive tract. Information

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LANGUAGE: eng

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AFFILIATION: Department of Otolaryngology, Bundang Jaesaeng General Hospital, Sungnam, South Korea.

Country: England

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MEDLINETA: Oral Oncol

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