18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis.

18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis. Research Abstract Details 

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18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis. Abstract Text:

Keitaro Yamanouchi,Erica Yada,Naomi Ishiguro,Masugi Nishihara,Keitaro Yamanouchi,Erica Yada,Naomi Ishiguro,Masugi Nishihara,

The importance of connexins is implicated in proliferation and differentiation of cells. In skeletal muscle cells, connexin43 (Cx43) has been identified as the major connexin, and gap-junctional communication mediated by connexins has been shown to be required for their myogenic differentiation. In addition, inhibition of connexin function has been shown to induce transdifferentiation of osteoblasts to an adipocytic phenotype. In the present study, we examined whether the inhibition of connexin function could induce phenotypic changes in skeletal muscle cells. Treatment of skeletal muscle cells with an inhibitor of connexin function, 18alpha-glycyrrhetinic acid (AGRA), resulted in a reduction in the number of MyoD-positive cells and complete inhibition of myotube formation, concomitantly with an increase in the number of C/EBPalpha-positive cells. AGRA-treated cells cultured in adipogenic differentiation medium could give rise to mature adipocytes that express both PPARgamma and C/EBPalpha. The presence of AGRA during adipogenic differentiation did not inhibit adipogenesis of skeletal muscle cells. AGRA treatment did not affect Cx43 expression in skeletal muscle cells but reduced its phosphorylation. These results indicate that inhibition of connexin function induces phenotypic changes of skeletal muscle cells to enter adipogenesis.

18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis. Publishing Authors By Initials

K Yamanouchi,E Yada,N Ishiguro,M Nishihara,K Yamanouchi,E Yada,N Ishiguro,M Nishihara,

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18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular physiology and biochemistry : internation

VOLUME: 20

Page Numbers: 781-90

Journal Abbreviation: Cell. Physiol. Biochem.

ISSN: 1015-8987

DAY: 5

MONTH: 11

YEAR: 2007

18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis. Information

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LANGUAGE: eng

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AFFILIATION: Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Tokyo, Japan. akeita@mail.ecc.u-tokyo.ac.jp

Country: Switzerland

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MEDLINETA: Cell Physiol Biochem

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